DegronMD

Uniprot ID: Q9Y467

Source protein: Sal-like protein 2

Source gene: SALL2

Class: DEG_APCC_DBOX_1

Location: 546:554

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6928

ASA_SCORE: 89.6333

COIL: 0.6161

CONS_SCORE: 0.3873

DSS_SCORE: 0.3017

HELIX: 0.1731

FCONS_SCORE: 0.9981

RIG_SCORE: 0.8032

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R547C	TCGA-19-5956	GBM	TCGA	TRMQLSKLV	DEG_APCC_DBOX_1	0.8301
p.V539M	TCGA-D7-5578	STAD	TCGA	TRMQLSKLV	DEG_APCC_DBOX_1	0.1389
p.S551I	TCGA-VQ-AA6A	STAD	TCGA	TRMQLSKLV	DEG_APCC_DBOX_1	0.623
p.T564I	DO51867	BLCA	ICGC	TRMQLSKLV	DEG_APCC_DBOX_1	0.0556
p.A546T	DO219050	BLCA	ICGC	TRMQLSKLV	DEG_APCC_DBOX_1	0.7139
p.F563L	DO7783	COAD	ICGC	TRMQLSKLV	DEG_APCC_DBOX_1	0.0833
p.T564A	DO233767	GACA	ICGC	TRMQLSKLV	DEG_APCC_DBOX_1	0.0556
p.K562R	DO47801	STAD	ICGC	TRMQLSKLV	DEG_APCC_DBOX_1	0.1111
p.R538H	DO40978	UCEC	ICGC	TRMQLSKLV	DEG_APCC_DBOX_1	0.1111
p.R538H	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	TRMQLSKLV	DEG_APCC_DBOX_1	0.1111
p.S555F	DO41572	UCEC	ICGC	TRMQLSKLV	DEG_APCC_DBOX_1	0.3056
p.R547H	SIDM00455	Pancreatic Carcinoma	GDSC	TRMQLSKLV	DEG_APCC_DBOX_1	0.8244
p.R547H	ACH-000599	Pancreatic Cancer	CCLE	TRMQLSKLV	DEG_APCC_DBOX_1	0.8244
p.R547H	PA-TU-8902	pancreas	COSMIC	TRMQLSKLV	DEG_APCC_DBOX_1	0.8244
p.L563P	SIDM00330	Neuroblastoma	GDSC	TRMQLSKLV	DEG_APCC_DBOX_1	0.0833
p.L563P	ACH-001355	Neuroblastoma	CCLE	TRMQLSKLV	DEG_APCC_DBOX_1	0.0833
p.L563P	LAN-6	autonomic_ganglia	COSMIC	TRMQLSKLV	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y467	Sal-like protein 2	DEG_APCC_DBOX_1	546:554	TRMQLSKLV	APC,CDC20,FZR1	0.6928	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons