DegronMD

Uniprot ID: Q9Y467

Source protein: Sal-like protein 2

Source gene: SALL2

Class: DEG_SCF_FBW7_2

Location: 879:884

E3 ligase: FBXW7

DEGRON score: 0.9921

ASA_SCORE: 79

COIL: 0.729

CONS_SCORE: 0.4439

DSS_SCORE: 0.6818

HELIX: 0.1482

FCONS_SCORE: 1.1016

RIG_SCORE: 0.6133

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P881R	TCGA-66-2765	LUSC	TCGA	LTPEGE	DEG_SCF_FBW7_2	0.7512
p.G883V	TCGA-BQ-7056	KIRP	TCGA	LTPEGE	DEG_SCF_FBW7_2	0.6421
p.A885V	DO233764	GACA	ICGC	LTPEGE	DEG_SCF_FBW7_2	0.3056
p.S873L	TCGA-4Z-AA7Y	BLCA	TCGA	LTPEGE	DEG_SCF_FBW7_2	0.1667
p.L890S	TCGA-CK-6746	COAD	TCGA	LTPEGE	DEG_SCF_FBW7_2	0.1667
p.E892Q	TCGA-XF-A8HH	BLCA	TCGA	LTPEGE	DEG_SCF_FBW7_2	0.1111
p.P892S	DO219002	BLCA	ICGC	LTPEGE	DEG_SCF_FBW7_2	0.1111
p.P869L	TCGA-A6-6649	COAD	TCGA	LTPEGE	DEG_SCF_FBW7_2	0.0556
p.P869L	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	LTPEGE	DEG_SCF_FBW7_2	0.0556
p.P869L	ACH-000665	Lung Cancer	CCLE	LTPEGE	DEG_SCF_FBW7_2	0.0556
p.P869L	SK-MES-1	lung	COSMIC	LTPEGE	DEG_SCF_FBW7_2	0.0556
p.P894S	DO222632	MELA	ICGC	LTPEGE	DEG_SCF_FBW7_2	0.0556

Showing 1 to 12 of 12 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y467	Sal-like protein 2	DEG_SCF_FBW7_2	879:884	LTPEGE	FBXW7	0.9921	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons