DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LTPEGE
Uniprot ID:
Q9Y467
Source protein:
Sal-like protein 2
Source gene:
SALL2
Class:
DEG_SCF_FBW7_2
Location:
879:884
E3 ligase:
FBXW7
DEGRON score:
0.9921
ASA_SCORE:
79
COIL:
0.729
CONS_SCORE:
0.4439
DSS_SCORE:
0.6818
HELIX:
0.1482
FCONS_SCORE:
1.1016
RIG_SCORE:
0.6133
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S873L
TCGA-4Z-AA7Y
BLCA
TCGA
LTPEGE
DEG_SCF_FBW7_2
0.1667
p.P881R
TCGA-66-2765
LUSC
TCGA
LTPEGE
DEG_SCF_FBW7_2
0.7512
p.P869L
TCGA-A6-6649
COAD
TCGA
LTPEGE
DEG_SCF_FBW7_2
0.0556
p.P869L
SIDM01103
Squamous Cell Lung Carcinoma
GDSC
LTPEGE
DEG_SCF_FBW7_2
0.0556
p.P869L
ACH-000665
Lung Cancer
CCLE
LTPEGE
DEG_SCF_FBW7_2
0.0556
p.P869L
SK-MES-1
lung
COSMIC
LTPEGE
DEG_SCF_FBW7_2
0.0556
p.G883V
TCGA-BQ-7056
KIRP
TCGA
LTPEGE
DEG_SCF_FBW7_2
0.6421
p.L890S
TCGA-CK-6746
COAD
TCGA
LTPEGE
DEG_SCF_FBW7_2
0.1667
p.E892Q
TCGA-XF-A8HH
BLCA
TCGA
LTPEGE
DEG_SCF_FBW7_2
0.1111
p.P892S
DO219002
BLCA
ICGC
LTPEGE
DEG_SCF_FBW7_2
0.1111
p.A885V
DO233764
GACA
ICGC
LTPEGE
DEG_SCF_FBW7_2
0.3056
p.P894S
DO222632
MELA
ICGC
LTPEGE
DEG_SCF_FBW7_2
0.0556
Drug responses associated with SALL2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LTPEGE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y467
Sal-like protein 2
DEG_SCF_FBW7_2
879:884
LTPEGE
FBXW7
0.9921
More...