DegronMD

Uniprot ID: O15083

Source protein: ERC protein 2

Source gene: ERC2

Class: DEG_SPOP_SBC_1

Location: 70:74

E3 ligase: SPOP

DEGRON score: 0.9875

ASA_SCORE: 65.7

COIL: 0.8384

CONS_SCORE: 0.3926

DSS_SCORE: 0.4058

HELIX: 0.0858

FCONS_SCORE: 0.8514

RIG_SCORE: 0.7257

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M80I	TCGA-GN-A4U4	SKCM	TCGA	VASTT	DEG_SPOP_SBC_1	0.1667
p.M80I	DO51256	SKCM	ICGC	VASTT	DEG_SPOP_SBC_1	0.1667
p.G69E	DO48368	BLCA	ICGC	VASTT	DEG_SPOP_SBC_1	0.3056
p.Y75H	DO234183	ESAD	ICGC	VASTT	DEG_SPOP_SBC_1	0.3056
p.G60R	DO222843	MELA	ICGC	VASTT	DEG_SPOP_SBC_1	0.0556
p.M80T	SIDM00150	Colorectal Carcinoma	GDSC	VASTT	DEG_SPOP_SBC_1	0.1667
p.M80T	ACH-000969	Colon/Colorectal Cancer	CCLE	VASTT	DEG_SPOP_SBC_1	0.1667
p.M80T	KM12	large_intestine	COSMIC	VASTT	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15083	ERC protein 2	DEG_SPOP_SBC_1	70:74	VASTT	SPOP	0.9875	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	249:253	VASTT	SPOP	0.9553	More...
P15144	Aminopeptidase N	DEG_SPOP_SBC_1	46:50	VASTT	SPOP	0.7621	More...
Q14CZ8	Hepatocyte cell adhesion molecule	DEG_SPOP_SBC_1	152:156	VASTT	SPOP	0.6335	More...
Q86V86	Serine/threonine-protein kinase pim-3	DEG_SPOP_SBC_1	316:320	VASTT	SPOP	0.7149	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	478:482	VASTT	SPOP	0.6062	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	129:133	VASTT	SPOP	0.8725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons