DegronMD

Uniprot ID: P15144

Source protein: Aminopeptidase N

Source gene: ANPEP

Class: DEG_SPOP_SBC_1

Location: 46:50

E3 ligase: SPOP

DEGRON score: 0.7621

ASA_SCORE: 91.16

COIL: 0.937

CONS_SCORE: 0.3521

DSS_SCORE: 0.5501

HELIX: 0.0216

FCONS_SCORE: 1.0202

RIG_SCORE: 0.6469

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N40K	TCGA-51-6867	LUSC	TCGA	VASTT	DEG_SPOP_SBC_1	0.1667
p.N40K	DO26477	LUSC	ICGC	VASTT	DEG_SPOP_SBC_1	0.1667
p.T57A	TCGA-55-7994	LUAD	TCGA	VASTT	DEG_SPOP_SBC_1	0.1389
p.T57A	DO45311	LUAD	ICGC	VASTT	DEG_SPOP_SBC_1	0.1389
p.P51L	TCGA-AJ-A3BH	UCEC	TCGA	VASTT	DEG_SPOP_SBC_1	0.3056
p.P51L	TCGA-XF-AAMY	BLCA	TCGA	VASTT	DEG_SPOP_SBC_1	0.3056
p.P51L	DO219050	BLCA	ICGC	VASTT	DEG_SPOP_SBC_1	0.3056
p.P51L	DO41638	UCEC	ICGC	VASTT	DEG_SPOP_SBC_1	0.3056
p.S52P	TCGA-AP-A1DK	UCEC	TCGA	VASTT	DEG_SPOP_SBC_1	0.2778
p.S52P	DO42033	UCEC	ICGC	VASTT	DEG_SPOP_SBC_1	0.2778
p.P45L	TCGA-D9-A6EA	SKCM	TCGA	VASTT	DEG_SPOP_SBC_1	0.3056
p.P45L	DO220906	MELA	ICGC	VASTT	DEG_SPOP_SBC_1	0.3056
p.P45L	DO50290	SKCM	ICGC	VASTT	DEG_SPOP_SBC_1	0.3056
p.P51S	TCGA-FR-A726	SKCM	TCGA	VASTT	DEG_SPOP_SBC_1	0.3056
p.P51S	DO48665	SKCM	ICGC	VASTT	DEG_SPOP_SBC_1	0.3056
p.T57I	TCGA-YL-A8SR	PRAD	TCGA	VASTT	DEG_SPOP_SBC_1	0.1389
p.T57I	DO51439	PRAD	ICGC	VASTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15083	ERC protein 2	DEG_SPOP_SBC_1	70:74	VASTT	SPOP	0.9875	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	249:253	VASTT	SPOP	0.9553	More...
P15144	Aminopeptidase N	DEG_SPOP_SBC_1	46:50	VASTT	SPOP	0.7621	More...
Q14CZ8	Hepatocyte cell adhesion molecule	DEG_SPOP_SBC_1	152:156	VASTT	SPOP	0.6335	More...
Q86V86	Serine/threonine-protein kinase pim-3	DEG_SPOP_SBC_1	316:320	VASTT	SPOP	0.7149	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	478:482	VASTT	SPOP	0.6062	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	129:133	VASTT	SPOP	0.8725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons