DegronMD - Q86V86(PIM3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A317S	DO229018	LICA	ICGC	VASTT	DEG_SPOP_SBC_1	316:320	Mutation altering degron motif	0.6477
p.S325I	DO50657	ORCA	ICGC	VASTT	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1944
p.R307L	DO229213	THCA	ICGC	VASTT	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.0833
p.P313S	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	VASTT	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.25
p.S322T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VASTT	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.2778
p.S322T	ACH-001127	Leukemia	CCLE	VASTT	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.2778
p.S322T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VASTT	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.2778
p.D315N	ACH-000997	Colon/Colorectal Cancer	CCLE	VASTT	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons