DegronMD

Uniprot ID: Q86V86

Source protein: Serine/threonine-protein kinase pim-3

Source gene: PIM3

Class: DEG_SPOP_SBC_1

Location: 316:320

E3 ligase: SPOP

DEGRON score: 0.7149

ASA_SCORE: 80.14

COIL: 0.8278

CONS_SCORE: 0.4109

DSS_SCORE: 0.5562

HELIX: 0.1456

FCONS_SCORE: 0.8635

RIG_SCORE: 0.7018

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A317S	DO229018	LICA	ICGC	VASTT	DEG_SPOP_SBC_1	0.6477
p.S325I	DO50657	ORCA	ICGC	VASTT	DEG_SPOP_SBC_1	0.1944
p.R307L	DO229213	THCA	ICGC	VASTT	DEG_SPOP_SBC_1	0.0833
p.P313S	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	VASTT	DEG_SPOP_SBC_1	0.25
p.S322T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VASTT	DEG_SPOP_SBC_1	0.2778
p.S322T	ACH-001127	Leukemia	CCLE	VASTT	DEG_SPOP_SBC_1	0.2778
p.S322T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VASTT	DEG_SPOP_SBC_1	0.2778
p.D315N	ACH-000997	Colon/Colorectal Cancer	CCLE	VASTT	DEG_SPOP_SBC_1	0.3056

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00145	ALL\|lymphoblastic_leukemia	p.A288T (No)	GDSC	PI-103	0.1685
SIDM00145	ALL\|lymphoblastic_leukemia	p.A288T (No)	GDSC	SL0101	23.8619
SIDM00145	ALL\|lymphoblastic_leukemia	p.A288T (No)	GDSC	AZD1208	10.0056
SIDM00145	ALL\|lymphoblastic_leukemia	p.A288T (No)	GDSC	AZD1208	116.94
SIDM00145	ALL\|lymphoblastic_leukemia	p.S322T (Yes)	GDSC	PI-103	0.1685
SIDM00145	ALL\|lymphoblastic_leukemia	p.S322T (Yes)	GDSC	SL0101	23.8619
SIDM00145	ALL\|lymphoblastic_leukemia	p.S322T (Yes)	GDSC	AZD1208	10.0056
SIDM00145	ALL\|lymphoblastic_leukemia	p.S322T (Yes)	GDSC	AZD1208	116.94
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.V239M (No)	GDSC	PI-103	0.0286
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.V239M (No)	GDSC	SL0101	55.0356
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.V239M (No)	GDSC	AZD1208	49.0196
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.V239M (No)	GDSC	AZD1208	114.01
SIDM01092	STAD\|stomach	p.P313S (Yes)	GDSC	PI-103	0.1945
SIDM01092	STAD\|stomach	p.P313S (Yes)	GDSC	SL0101	44.8441
SIDM01092	STAD\|stomach	p.P313S (Yes)	GDSC	AZD1208	150.5283
SIDM01092	STAD\|stomach	p.P313S (Yes)	GDSC	AZD1208	195.72
SIDM00951	LAML\|acute_myeloid_leukaemia	p.G16fs*8 (No)	GDSC	PI-103	1.081
SIDM00951	LAML\|acute_myeloid_leukaemia	p.G16fs*8 (No)	GDSC	SL0101	39.8103
SIDM00951	LAML\|acute_myeloid_leukaemia	p.G16fs*8 (No)	GDSC	AZD1208	4.1113
SIDM00951	LAML\|acute_myeloid_leukaemia	p.G16fs*8 (No)	GDSC	AZD1208	25.439

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15083	ERC protein 2	DEG_SPOP_SBC_1	70:74	VASTT	SPOP	0.9875	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	249:253	VASTT	SPOP	0.9553	More...
P15144	Aminopeptidase N	DEG_SPOP_SBC_1	46:50	VASTT	SPOP	0.7621	More...
Q14CZ8	Hepatocyte cell adhesion molecule	DEG_SPOP_SBC_1	152:156	VASTT	SPOP	0.6335	More...
Q86V86	Serine/threonine-protein kinase pim-3	DEG_SPOP_SBC_1	316:320	VASTT	SPOP	0.7149	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	478:482	VASTT	SPOP	0.6062	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	129:133	VASTT	SPOP	0.8725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons