DegronMD

Uniprot ID: P15822

Source protein: Zinc finger protein 40

Source gene: HIVEP1

Class: DEG_APCC_DBOX_1

Location: 1282:1290

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6297

ASA_SCORE: 113.3889

COIL: 0.5646

CONS_SCORE: 0.374

DSS_SCORE: 0.5362

HELIX: 0.3839

FCONS_SCORE: 0.9877

RIG_SCORE: 0.7223

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1285C	TCGA-AJ-A3EK	UCEC	TCGA	KRLRLAEIE	DEG_APCC_DBOX_1	0.719
p.R1285C	DO41584	UCEC	ICGC	KRLRLAEIE	DEG_APCC_DBOX_1	0.719
p.K1281N	TCGA-AK-3456	KIRC	TCGA	KRLRLAEIE	DEG_APCC_DBOX_1	0.3056
p.K1281N	DO16910	KIRC	ICGC	KRLRLAEIE	DEG_APCC_DBOX_1	0.3056
p.S1297R	TCGA-AP-A1DV	UCEC	TCGA	KRLRLAEIE	DEG_APCC_DBOX_1	0.1389
p.S1297R	DO43186	UCEC	ICGC	KRLRLAEIE	DEG_APCC_DBOX_1	0.1389
p.E1290Q	TCGA-BH-A0B6	BRCA	TCGA	KRLRLAEIE	DEG_APCC_DBOX_1	0.5633
p.E1290Q	DO2641	BRCA	ICGC	KRLRLAEIE	DEG_APCC_DBOX_1	0.5633
p.L1284I	TCGA-EO-A3KX	UCEC	TCGA	KRLRLAEIE	DEG_APCC_DBOX_1	0.6063
p.L1284I	DO219774	UCEC	ICGC	KRLRLAEIE	DEG_APCC_DBOX_1	0.6063
p.E1288D	DO229045	LICA	ICGC	KRLRLAEIE	DEG_APCC_DBOX_1	0.5647
p.S1292F	DO49137	PACA	ICGC	KRLRLAEIE	DEG_APCC_DBOX_1	0.2778
p.D1299E	SIDM00950	Pancreatic Carcinoma	GDSC	KRLRLAEIE	DEG_APCC_DBOX_1	0.0833
p.D1299E	ACH-000243	Pancreatic Cancer	CCLE	KRLRLAEIE	DEG_APCC_DBOX_1	0.0833
p.D1299E	DAN-G	pancreas	COSMIC	KRLRLAEIE	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15822	Zinc finger protein 40	DEG_APCC_DBOX_1	1282:1290	KRLRLAEIE	APC,CDC20,FZR1	0.6297	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons