DegronMD

Uniprot ID: P15822

Source protein: Zinc finger protein 40

Source gene: HIVEP1

Class: LIG_APCC_ABBA_1

Location: 483:488

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9397

ASA_SCORE: 79.7333

COIL: 0.5752

CONS_SCORE: 0.2407

DSS_SCORE: 0.641

HELIX: 0.0267

FCONS_SCORE: 0.6899

RIG_SCORE: 0.6639

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V489I	TCGA-32-2494	GBM	TCGA	LSIHSD	LIG_APCC_ABBA_1	0.3056
p.V489I	DO11998	GBM	ICGC	LSIHSD	LIG_APCC_ABBA_1	0.3056
p.L473V	TCGA-AA-A00N	COAD	TCGA	LSIHSD	LIG_APCC_ABBA_1	0.0556
p.L473V	DO9876	COAD	ICGC	LSIHSD	LIG_APCC_ABBA_1	0.0556
p.S492C	TCGA-D5-6932	COAD	TCGA	LSIHSD	LIG_APCC_ABBA_1	0.6667
p.S492C	DO9378	COAD	ICGC	LSIHSD	LIG_APCC_ABBA_1	0.6667
p.K481T	TCGA-QF-A5YS	UCEC	TCGA	LSIHSD	LIG_APCC_ABBA_1	0.2778
p.K481T	DO52426	UCEC	ICGC	LSIHSD	LIG_APCC_ABBA_1	0.2778
p.G493V	DO228952	LICA	ICGC	LSIHSD	LIG_APCC_ABBA_1	0.1944
p.G493V	DO229027	LICA	ICGC	LSIHSD	LIG_APCC_ABBA_1	0.1944
p.P480R	DO230918	LUSC	ICGC	LSIHSD	LIG_APCC_ABBA_1	0.25
p.P480R	DO224546	LUSC	ICGC	LSIHSD	LIG_APCC_ABBA_1	0.25
p.L473F	DO46372	OV	ICGC	LSIHSD	LIG_APCC_ABBA_1	0.0556
p.R473Q	NCI-H1793	lung	COSMIC	LSIHSD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15822	Zinc finger protein 40	LIG_APCC_ABBA_1	483:488	LSIHSD	APC,CDC20,FZR1	0.9397	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons