DegronMD

Uniprot ID: P15822

Source protein: Zinc finger protein 40

Source gene: HIVEP1

Class: LIG_APCC_ABBAyCdc20_2

Location: 784:790

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9879

ASA_SCORE: 108.8714

COIL: 0.8433

CONS_SCORE: 0.3801

DSS_SCORE: 0.3808

HELIX: 0.0544

FCONS_SCORE: 0.8602

RIG_SCORE: 0.7763

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G778R	TCGA-17-Z057	LUAD	TCGA	KSYIFKD	LIG_APCC_ABBAyCdc20_2	0.1667
p.S791C	TCGA-B6-A0IJ	BRCA	TCGA	KSYIFKD	LIG_APCC_ABBAyCdc20_2	0.75
p.S791C	DO2813	BRCA	ICGC	KSYIFKD	LIG_APCC_ABBAyCdc20_2	0.75
p.D790Y	TCGA-BS-A0UV	UCEC	TCGA	KSYIFKD	LIG_APCC_ABBAyCdc20_2	0.7325
p.D790Y	DO42793	UCEC	ICGC	KSYIFKD	LIG_APCC_ABBAyCdc20_2	0.7325
p.L774P	DO233892	GACA	ICGC	KSYIFKD	LIG_APCC_ABBAyCdc20_2	0.0556
p.D781H	DO220886	MELA	ICGC	KSYIFKD	LIG_APCC_ABBAyCdc20_2	0.25
p.G778E	DO46336	OV	ICGC	KSYIFKD	LIG_APCC_ABBAyCdc20_2	0.1667
p.P783L	ACH-000695	Lung Cancer	CCLE	KSYIFKD	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15822	Zinc finger protein 40	LIG_APCC_ABBAyCdc20_2	784:790	KSYIFKD	APC,CDC20,FZR1	0.9879	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons