DegronMD

Uniprot ID: Q9HCM4

Source protein: Band 4.1-like protein 5

Source gene: EPB41L5

Class: DEG_SCF_FBW7_1

Location: 617:624

E3 ligase: FBXW7

DEGRON score: 0.7547

ASA_SCORE: 89.075

COIL: 0.841

CONS_SCORE: 0.5348

DSS_SCORE: 0.3405

HELIX: 0.1171

FCONS_SCORE: 1.0555

RIG_SCORE: 0.7682

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P607S	TCGA-A6-5665	COAD	TCGA	MLITPADS	DEG_SCF_FBW7_1	0.0556
p.P607S	TCGA-BR-8680	STAD	TCGA	MLITPADS	DEG_SCF_FBW7_1	0.0556
p.P607S	DO9756	COAD	ICGC	MLITPADS	DEG_SCF_FBW7_1	0.0556
p.P607S	DO47769	STAD	ICGC	MLITPADS	DEG_SCF_FBW7_1	0.0556
p.M617I	TCGA-BH-A0DK	BRCA	TCGA	MLITPADS	DEG_SCF_FBW7_1	0.6507
p.M617I	DO1305	BRCA	ICGC	MLITPADS	DEG_SCF_FBW7_1	0.6507
p.E634K	TCGA-VS-A9UP	CESC	TCGA	MLITPADS	DEG_SCF_FBW7_1	0.0556
p.E634K	DO219737	CESC	ICGC	MLITPADS	DEG_SCF_FBW7_1	0.0556
p.E614Q	DO225140	BRCA	ICGC	MLITPADS	DEG_SCF_FBW7_1	0.25
p.L608F	DO218874	SKCA	ICGC	MLITPADS	DEG_SCF_FBW7_1	0.0833
p.M617K	SIDM01112	Osteosarcoma	GDSC	MLITPADS	DEG_SCF_FBW7_1	0.8062
p.M617K	SIDM00650	Small Cell Lung Carcinoma	GDSC	MLITPADS	DEG_SCF_FBW7_1	0.8062
p.M617K	SIDM00032	Bladder Carcinoma	GDSC	MLITPADS	DEG_SCF_FBW7_1	0.8062
p.M617K	SIDM00882	Breast Carcinoma	GDSC	MLITPADS	DEG_SCF_FBW7_1	0.8062
p.M617K	SIDM01681	Non-Cancerous	GDSC	MLITPADS	DEG_SCF_FBW7_1	0.8062
p.M617K	SIDM00760	Small Cell Lung Carcinoma	GDSC	MLITPADS	DEG_SCF_FBW7_1	0.8062
p.M617K	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	MLITPADS	DEG_SCF_FBW7_1	0.8062

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCM4	Band 4.1-like protein 5	DEG_SCF_FBW7_1	617:624	MLITPADS	FBXW7	0.7547	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons