DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VETPDSS
Uniprot ID:
Q2T9L4
Source protein:
Inhibitory synaptic factor 1
Source gene:
INSYN1
Class:
DEG_SCF_FBW7_1
Location:
154:160
E3 ligase:
FBXW7
DEGRON score:
0.993
ASA_SCORE:
79.2286
COIL:
0.8911
CONS_SCORE:
0.814
DSS_SCORE:
0.7589
HELIX:
0.0383
FCONS_SCORE:
1.1211
RIG_SCORE:
0.6151
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T146M
SIDM00178
Melanoma
GDSC
VETPDSS
DEG_SCF_FBW7_1
0.5556
p.T146M
SIDM01575
Plasma Cell Myeloma
GDSC
VETPDSS
DEG_SCF_FBW7_1
0.5556
Drug responses associated with INSYN1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VETPDSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q2T9L4
Inhibitory synaptic factor 1
DEG_SCF_FBW7_1
154:160
VETPDSS
FBXW7
0.993
More...