DegronMD

Uniprot ID: P01266

Source protein: Thyroglobulin

Source gene: TG

Class: DEG_APCC_DBOX_1

Location: 2751:2759

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5989

ASA_SCORE: 78.2556

COIL: 0.5264

CONS_SCORE: 0.2577

DSS_SCORE: 0.6429

HELIX: 0.3161

FCONS_SCORE: 0.6924

RIG_SCORE: 0.732

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L2745F	TCGA-29-1694	OV	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	0.1667
p.S2757T	TCGA-86-8672	LUAD	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	0.6005
p.G2748A	TCGA-BA-A6DA	HNSC	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	0.25
p.S2763T	TCGA-CC-A9FW	LIHC	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	0.2222
p.S2757R	TCGA-D1-A15X	UCEC	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	0.6316
p.Y2766C	TCGA-D1-A1NY	UCEC	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	0.1389
p.E2743D	TCGA-D1-A2G0	UCEC	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	0.1111
p.E2742K	TCGA-D3-A8GL	SKCM	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	0.0833
p.E2753K	TCGA-EK-A3GK	CESC	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	0.591
p.A2747T	TCGA-GN-A26C	SKCM	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	0.2222
p.E2741K	TCGA-H4-A2HQ	BLCA	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	0.0556
p.T2746M	TCGA-RP-A690	SKCM	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	0.1944
p.E2744K	TCGA-W3-AA21	SKCM	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	0.1389
p.E2741G	SIDM00722	Mesothelioma	GDSC	LREDLLSLQ	DEG_APCC_DBOX_1	0.0556
p.E2741G	NCI-H2452	pleura	COSMIC	LREDLLSLQ	DEG_APCC_DBOX_1	0.0556
p.L2758F	SIDM00190	Melanoma	GDSC	LREDLLSLQ	DEG_APCC_DBOX_1	0.6981
p.L2758F	ACH-002097	Skin Cancer	CCLE	LREDLLSLQ	DEG_APCC_DBOX_1	0.6981
p.L2758F	CP66-MEL	skin	COSMIC	LREDLLSLQ	DEG_APCC_DBOX_1	0.6981
p.L2756R	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	LREDLLSLQ	DEG_APCC_DBOX_1	0.7316
p.L2756R	ACH-002221	Lymphoma	CCLE	LREDLLSLQ	DEG_APCC_DBOX_1	0.7316
p.L2756R	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LREDLLSLQ	DEG_APCC_DBOX_1	0.7316

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01266	Thyroglobulin	DEG_APCC_DBOX_1	2751:2759	LREDLLSLQ	APC,CDC20,FZR1	0.5989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons