DegronMD

Uniprot ID: Q6PCT2

Source protein: F-box/LRR-repeat protein 19

Source gene: FBXL19

Class: DEG_APCC_DBOX_1

Location: 567:575

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9015

ASA_SCORE: 43.2333

COIL: 0.781

CONS_SCORE: 0.6382

DSS_SCORE: 0.4689

HELIX: 0.1184

FCONS_SCORE: 0.9926

RIG_SCORE: 0.716

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R578C	TCGA-24-1423	OV	TCGA	SRGRLQGVA	DEG_APCC_DBOX_1	0.25
p.A580G	TCGA-AC-A6IW	BRCA	TCGA	SRGRLQGVA	DEG_APCC_DBOX_1	0.1944
p.G573W	TCGA-ER-A19P	SKCM	TCGA	SRGRLQGVA	DEG_APCC_DBOX_1	0.6714
p.G581D	TCGA-F4-6809	COAD	TCGA	SRGRLQGVA	DEG_APCC_DBOX_1	0.1667
p.R578H	TCGA-G4-6309	COAD	TCGA	SRGRLQGVA	DEG_APCC_DBOX_1	0.25
p.R568C	TCGA-XK-AAIW	PRAD	TCGA	SRGRLQGVA	DEG_APCC_DBOX_1	0.8301
p.A560G	DO50028	BRCA	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	0.5833
p.G561D	DO10164	COAD	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	0.6111
p.R558H	DO7810	COAD	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	0.0833
p.R558H	DO233168	GACA	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	0.0833
p.D583E	DO52483	COCA	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	0.1111
p.A581T	DO233644	GACA	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	0.1667
p.A581T	DO28062	OV	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	0.1667
p.A581T	DO223286	UCEC	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	0.1667
p.A576S	DO228974	LICA	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	0.3056
p.G561V	DO229028	LICA	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	0.6111
p.R570H	DO52674	MALY	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	0.7133
p.R558C	DO30080	OV	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	0.0833
p.R558C	DO229257	THCA	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	0.0833
p.A576T	DO42713	UCEC	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	0.3056
p.R574H	EoL-1-cell	haematopoietic_and_lymphoid_tissue	COSMIC	SRGRLQGVA	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PCT2	F-box/LRR-repeat protein 19	DEG_APCC_DBOX_1	567:575	SRGRLQGVA	APC,CDC20,FZR1	0.9015	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons