DegronMD

Uniprot ID: Q6PCT2

Source protein: F-box/LRR-repeat protein 19

Source gene: FBXL19

Class: DEG_COP1_1

Location: 291:300

E3 ligase: COP1

DEGRON score: 0.9834

ASA_SCORE: 84.2

COIL: 0.9338

CONS_SCORE: 0.6289

DSS_SCORE: 0.7042

HELIX: 0.0441

FCONS_SCORE: 1.0242

RIG_SCORE: 0.5498

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A292T	TCGA-AB-2807	LAML	TCGA	SAEGPAVPSP	DEG_COP1_1	0.6028
p.R309C	TCGA-AP-A1DV	UCEC	TCGA	SAEGPAVPSP	DEG_COP1_1	0.0833
p.W282R	TCGA-BG-A222	UCEC	TCGA	SAEGPAVPSP	DEG_COP1_1	0.0833
p.R309H	TCGA-MN-A4N5	LUAD	TCGA	SAEGPAVPSP	DEG_COP1_1	0.0833
p.R309H	SIDM01693	B-Lymphoblastic Leukemia	GDSC	SAEGPAVPSP	DEG_COP1_1	0.0833
p.R309H	ACH-000032	Leukemia	CCLE	SAEGPAVPSP	DEG_COP1_1	0.0833
p.P287L	TCGA-WS-AB45	COAD	TCGA	SAEGPAVPSP	DEG_COP1_1	0.2222
p.S308L	DO51903	BLCA	ICGC	SAEGPAVPSP	DEG_COP1_1	0.1111
p.S306A	DO11507	GBM	ICGC	SAEGPAVPSP	DEG_COP1_1	0.2778
p.L297M	DO14766	HNSC	ICGC	SAEGPAVPSP	DEG_COP1_1	0.711
p.R299L	DO25837	LUAD	ICGC	SAEGPAVPSP	DEG_COP1_1	0.8428
p.R289H	DO45332	LUAD	ICGC	SAEGPAVPSP	DEG_COP1_1	0.2778
p.S305Y	DO47407	SKCM	ICGC	SAEGPAVPSP	DEG_COP1_1	0.1944
p.R289C	DO43186	UCEC	ICGC	SAEGPAVPSP	DEG_COP1_1	0.2778
p.P300L	SIDM00958	Chronic Myelogenous Leukemia	GDSC	SAEGPAVPSP	DEG_COP1_1	0.6471
p.P300L	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	SAEGPAVPSP	DEG_COP1_1	0.6471
p.P300L	ACH-000917	Esophageal Cancer	CCLE	SAEGPAVPSP	DEG_COP1_1	0.6471
p.P300L	ACH-000920	Leukemia	CCLE	SAEGPAVPSP	DEG_COP1_1	0.6471
p.P300L	TE-4	oesophagus	COSMIC	SAEGPAVPSP	DEG_COP1_1	0.6471
p.P300L	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	SAEGPAVPSP	DEG_COP1_1	0.6471
p.E308Q	SIDM00938	Breast Carcinoma	GDSC	SAEGPAVPSP	DEG_COP1_1	0.1111
p.E308Q	ACH-000902	Breast Cancer	CCLE	SAEGPAVPSP	DEG_COP1_1	0.1111
p.E308Q	CAL-148	breast	COSMIC	SAEGPAVPSP	DEG_COP1_1	0.1111
p.P300S	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	SAEGPAVPSP	DEG_COP1_1	0.6752
p.P300S	ACH-000809	Esophageal Cancer	CCLE	SAEGPAVPSP	DEG_COP1_1	0.6752
p.P300S	KYSE-410	oesophagus	COSMIC	SAEGPAVPSP	DEG_COP1_1	0.6752
p.G294D	SIDM00299	Other Sarcomas	GDSC	SAEGPAVPSP	DEG_COP1_1	0.6087
p.G294D	ACH-002271	Sarcoma	CCLE	SAEGPAVPSP	DEG_COP1_1	0.6087
p.G294D	MFH-ino	soft_tissue	COSMIC	SAEGPAVPSP	DEG_COP1_1	0.6087
p.V297L	SIDM01473	Plasma Cell Myeloma	GDSC	SAEGPAVPSP	DEG_COP1_1	0.6765
p.A296T	ACH-000967	Colon/Colorectal Cancer	CCLE	SAEGPAVPSP	DEG_COP1_1	0.6028
p.A296T	ACH-001199	Colon/Colorectal Cancer	CCLE	SAEGPAVPSP	DEG_COP1_1	0.6028
p.A296T	ACH-001738	Leukemia	CCLE	SAEGPAVPSP	DEG_COP1_1	0.6028
p.A296T	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	SAEGPAVPSP	DEG_COP1_1	0.6028
p.T310M	ACH-002250	Head and Neck Cancer	CCLE	SAEGPAVPSP	DEG_COP1_1	0.0556
p.T310M	JHU-022	upper_aerodigestive_tract	COSMIC	SAEGPAVPSP	DEG_COP1_1	0.0556
p.S304T	DOV13	ovary	COSMIC	SAEGPAVPSP	DEG_COP1_1	0.2222
p.R282H	EoL-1-cell	haematopoietic_and_lymphoid_tissue	COSMIC	SAEGPAVPSP	DEG_COP1_1	0.0833
p.E288Q	CAL-148	breast	COSMIC	SAEGPAVPSP	DEG_COP1_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SAEGPAVPSP

Degron related mutations and impact score

Drug responses associated with FBXL19 mutations

All proteins holding degron of SAEGPAVPSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PCT2	F-box/LRR-repeat protein 19	DEG_COP1_1	291:300	SAEGPAVPSP	COP1	0.9834	More...