DegronMD

Uniprot ID: Q6PCT2

Source protein: F-box/LRR-repeat protein 19

Source gene: FBXL19

Class: DEG_SCF_FBW7_1

Location: 16:22

E3 ligase: FBXW7

DEGRON score: 0.869

ASA_SCORE: 94.0286

COIL: 0.9471

CONS_SCORE: 0.3379

DSS_SCORE: 0.7541

HELIX: 0.0216

FCONS_SCORE: 0.8298

RIG_SCORE: 0.6238

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G7R	TCGA-B6-A0RL	BRCA	TCGA	LLTPPMS	DEG_SCF_FBW7_1	0.0833
p.G7R	DO3644	BRCA	ICGC	LLTPPMS	DEG_SCF_FBW7_1	0.0833
p.C25S	DO225195	BRCA	ICGC	LLTPPMS	DEG_SCF_FBW7_1	0.25
p.E10K	DO229010	COCA	ICGC	LLTPPMS	DEG_SCF_FBW7_1	0.1667
p.E10K	DO229013	COCA	ICGC	LLTPPMS	DEG_SCF_FBW7_1	0.1667
p.R20H	DO223130	ESCA	ICGC	LLTPPMS	DEG_SCF_FBW7_1	0.8244
p.R13C	DO20780	KIRP	ICGC	LLTPPMS	DEG_SCF_FBW7_1	0.25
p.R18L	DO228948	LICA	ICGC	LLTPPMS	DEG_SCF_FBW7_1	0.8428
p.R15L	DO229022	LICA	ICGC	LLTPPMS	DEG_SCF_FBW7_1	0.3056
p.C25F	DO229027	LICA	ICGC	LLTPPMS	DEG_SCF_FBW7_1	0.25
p.G9R	DO50970	LICA	ICGC	LLTPPMS	DEG_SCF_FBW7_1	0.1389
p.R13H	DO23368	LINC	ICGC	LLTPPMS	DEG_SCF_FBW7_1	0.25
p.P6S	DO222595	MELA	ICGC	LLTPPMS	DEG_SCF_FBW7_1	0.0556
p.R27L	DO50268	PAAD	ICGC	LLTPPMS	DEG_SCF_FBW7_1	0.1944
p.G31E	DO219387	PRAD	ICGC	LLTPPMS	DEG_SCF_FBW7_1	0.0833
p.T28S	DO43755	UCEC	ICGC	LLTPPMS	DEG_SCF_FBW7_1	0.1667
p.G27V	SIDM01622	Breast Carcinoma	GDSC	LLTPPMS	DEG_SCF_FBW7_1	0.1944
p.G27V	ACH-000721	Breast Cancer	CCLE	LLTPPMS	DEG_SCF_FBW7_1	0.1944
p.S22L	ACH-000441	Skin Cancer	CCLE	LLTPPMS	DEG_SCF_FBW7_1	0.7667
p.D21N	ACH-000984	Endometrial/Uterine Cancer	CCLE	LLTPPMS	DEG_SCF_FBW7_1	0.6932
p.S12T	DOV13	ovary	COSMIC	LLTPPMS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PCT2	F-box/LRR-repeat protein 19	DEG_SCF_FBW7_1	16:22	LLTPPMS	FBXW7	0.869	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons