DegronMD

Uniprot ID: Q9P265

Source protein: Disco-interacting protein 2 homolog B

Source gene: DIP2B

Class: LIG_APCC_ABBAyCdc20_2

Location: 99:105

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9941

ASA_SCORE: 87.2429

COIL: 0.5456

CONS_SCORE: 0.1555

DSS_SCORE: 0.5619

HELIX: 0.4341

FCONS_SCORE: 1.0886

RIG_SCORE: 0.7253

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D95Y	TCGA-38-4625	LUAD	TCGA	RSDIHTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.D95Y	DO23952	LUAD	ICGC	RSDIHTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R89L	DO229038	LICA	ICGC	RSDIHTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.K115E	DO50850	LIRI	ICGC	RSDIHTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.A109P	SIDM00516	Melanoma	GDSC	RSDIHTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A109P	SIDM01879	Non-Cancerous	GDSC	RSDIHTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A109P	ACH-002361	Non-Cancerous	CCLE	RSDIHTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.D95V	ACH-000973	Bladder Cancer	CCLE	RSDIHTE	LIG_APCC_ABBAyCdc20_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P265	Disco-interacting protein 2 homolog B	LIG_APCC_ABBAyCdc20_2	99:105	RSDIHTE	APC,CDC20,FZR1	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons