DegronMD

Uniprot ID: Q12830

Source protein: Nucleosome-remodeling factor subunit BPTF

Source gene: BPTF

Class: DEG_SCF_FBW7_1

Location: 2336:2342

E3 ligase: FBXW7

DEGRON score: 0.5099

ASA_SCORE: 97.1857

COIL: 0.8833

CONS_SCORE: 0.4601

DSS_SCORE: 0.3978

HELIX: 0.0236

FCONS_SCORE: 1.1849

RIG_SCORE: 0.8403

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2339F	TCGA-B5-A11E	UCEC	TCGA	LFTPLAT	DEG_SCF_FBW7_1	0.7982
p.S2339F	DO41644	UCEC	ICGC	LFTPLAT	DEG_SCF_FBW7_1	0.7982
p.R2342H	TCGA-HZ-7289	PAAD	TCGA	LFTPLAT	DEG_SCF_FBW7_1	0.8244
p.R2342H	DO32793	PAAD	ICGC	LFTPLAT	DEG_SCF_FBW7_1	0.8244
p.R2352C	DO8898	COAD	ICGC	LFTPLAT	DEG_SCF_FBW7_1	0.0556
p.R2342C	SIDM00534	Colorectal Carcinoma	GDSC	LFTPLAT	DEG_SCF_FBW7_1	0.8301
p.R2342C	ACH-000986	Colon/Colorectal Cancer	CCLE	LFTPLAT	DEG_SCF_FBW7_1	0.8301
p.R2342C	HT-115	large_intestine	COSMIC	LFTPLAT	DEG_SCF_FBW7_1	0.8301
p.P2346L	Sarc9371	bone	COSMIC	LFTPLAT	DEG_SCF_FBW7_1	0.6667
p.P2333L	Sarc9371	bone	COSMIC	LFTPLAT	DEG_SCF_FBW7_1	0.25
p.A2326V	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LFTPLAT	DEG_SCF_FBW7_1	0.0556
p.R2329C	HT-115	large_intestine	COSMIC	LFTPLAT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SCF_FBW7_1	2336:2342	LFTPLAT	FBXW7	0.5099	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons