DegronMD

Uniprot ID: Q12830

Source protein: Nucleosome-remodeling factor subunit BPTF

Source gene: BPTF

Class: DEG_Kelch_Keap1_1

Location: 729:734

E3 ligase: KEAP1

DEGRON score: 0.9912

ASA_SCORE: 90.8167

COIL: 0.7848

CONS_SCORE: 0.2894

DSS_SCORE: 0.7994

HELIX: 0.1967

FCONS_SCORE: 1.0484

RIG_SCORE: 0.5312

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R723P	TCGA-A5-A0GE	UCEC	TCGA	DPENGE	DEG_Kelch_Keap1_1	0.1667
p.R723P	DO42424	UCEC	ICGC	DPENGE	DEG_Kelch_Keap1_1	0.1667
p.N727S	TCGA-CQ-6219	HNSC	TCGA	DPENGE	DEG_Kelch_Keap1_1	0.2778
p.N727S	DO15054	HNSC	ICGC	DPENGE	DEG_Kelch_Keap1_1	0.2778
p.R723H	TCGA-F5-6814	READ	TCGA	DPENGE	DEG_Kelch_Keap1_1	0.1667
p.R723H	DO36556	READ	ICGC	DPENGE	DEG_Kelch_Keap1_1	0.1667
p.E722K	DO217844	BRCA	ICGC	DPENGE	DEG_Kelch_Keap1_1	0.1389
p.R735T	DO217844	BRCA	ICGC	DPENGE	DEG_Kelch_Keap1_1	0.3056
p.E734Q	DO224768	BRCA	ICGC	DPENGE	DEG_Kelch_Keap1_1	0.6744
p.Q744E	DO9924	COAD	ICGC	DPENGE	DEG_Kelch_Keap1_1	0.0556
p.P740H	DO14766	HNSC	ICGC	DPENGE	DEG_Kelch_Keap1_1	0.1667
p.P730H	DO14190	HNSC	ICGC	DPENGE	DEG_Kelch_Keap1_1	0.6583
p.V724F	DO228952	LICA	ICGC	DPENGE	DEG_Kelch_Keap1_1	0.1944
p.S721I	DO229015	LICA	ICGC	DPENGE	DEG_Kelch_Keap1_1	0.1111
p.Q744H	DO26596	LUSC	ICGC	DPENGE	DEG_Kelch_Keap1_1	0.0556
p.R723C	SIDM00490	Glioma	GDSC	DPENGE	DEG_Kelch_Keap1_1	0.1667
p.R723C	Becker	central_nervous_system	COSMIC	DPENGE	DEG_Kelch_Keap1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_Kelch_Keap1_1	729:734	DPENGE	KEAP1	0.9912	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons