DegronMD

Uniprot ID: Q12830

Source protein: Nucleosome-remodeling factor subunit BPTF

Source gene: BPTF

Class: DEG_SCF_FBW7_1

Location: 1998:2004

E3 ligase: FBXW7

DEGRON score: 0.7798

ASA_SCORE: 117.2429

COIL: 0.9364

CONS_SCORE: 0.5346

DSS_SCORE: 0.5658

HELIX: 0.0194

FCONS_SCORE: 0.894

RIG_SCORE: 0.633

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V2001I	TCGA-AJ-A3EL	UCEC	TCGA	PETPKQT	DEG_SCF_FBW7_1	0.7076
p.V2001I	TCGA-XD-AAUI	PAAD	TCGA	PETPKQT	DEG_SCF_FBW7_1	0.7076
p.V2001I	DO51722	PAAD	ICGC	PETPKQT	DEG_SCF_FBW7_1	0.7076
p.V2001I	DO41542	UCEC	ICGC	PETPKQT	DEG_SCF_FBW7_1	0.7076
p.V2004L	DO229041	LICA	ICGC	PETPKQT	DEG_SCF_FBW7_1	0.6765
p.Q1996H	DO232761	PBCA	ICGC	PETPKQT	DEG_SCF_FBW7_1	0.7222
p.T1990I	SIDM01608	Endometrial Carcinoma	GDSC	PETPKQT	DEG_SCF_FBW7_1	0.1111
p.T1990I	ACH-000990	Endometrial/Uterine Cancer	CCLE	PETPKQT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SCF_FBW7_1	1998:2004	PETPKQT	FBXW7	0.7798	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons