DegronMD

Uniprot ID: Q12830

Source protein: Nucleosome-remodeling factor subunit BPTF

Source gene: BPTF

Class: DEG_SCF_FBW7_1

Location: 1973:1980

E3 ligase: FBXW7

DEGRON score: 0.9955

ASA_SCORE: 106.2375

COIL: 0.9451

CONS_SCORE: 0.4331

DSS_SCORE: 0.5451

HELIX: 0.0121

FCONS_SCORE: 0.7006

RIG_SCORE: 0.6803

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1987I	TCGA-50-6592	LUAD	TCGA	VPETPKET	DEG_SCF_FBW7_1	0.1389
p.T1987I	DO23742	LUAD	ICGC	VPETPKET	DEG_SCF_FBW7_1	0.1389
p.K1963R	TCGA-B5-A3FA	UCEC	TCGA	VPETPKET	DEG_SCF_FBW7_1	0.0556
p.K1963R	DO52402	UCEC	ICGC	VPETPKET	DEG_SCF_FBW7_1	0.0556
p.H1985D	DO875	BOCA	ICGC	VPETPKET	DEG_SCF_FBW7_1	0.1944
p.N1981H	DO224977	BRCA	ICGC	VPETPKET	DEG_SCF_FBW7_1	0.3056
p.N1981K	DO229038	LICA	ICGC	VPETPKET	DEG_SCF_FBW7_1	0.3056
p.N1983S	DO229264	THCA	ICGC	VPETPKET	DEG_SCF_FBW7_1	0.25
p.V1976L	SIDM00683	Prostate Carcinoma	GDSC	VPETPKET	DEG_SCF_FBW7_1	0.6765
p.V1976L	LNCaP-Clone-FGC	prostate	COSMIC	VPETPKET	DEG_SCF_FBW7_1	0.6765
p.T1990I	SIDM01608	Endometrial Carcinoma	GDSC	VPETPKET	DEG_SCF_FBW7_1	0.0556
p.T1990I	ACH-000990	Endometrial/Uterine Cancer	CCLE	VPETPKET	DEG_SCF_FBW7_1	0.0556
p.V1963L	LNCaP-Clone-FGC	prostate	COSMIC	VPETPKET	DEG_SCF_FBW7_1	0.0556
p.R1985K	JVM-3	haematopoietic_and_lymphoid_tissue	COSMIC	VPETPKET	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SCF_FBW7_1	1973:1980	VPETPKET	FBXW7	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons