DegronMD

Uniprot ID: Q12830

Source protein: Nucleosome-remodeling factor subunit BPTF

Source gene: BPTF

Class: DEG_SPOP_SBC_1

Location: 2493:2497

E3 ligase: SPOP

DEGRON score: 0.9806

ASA_SCORE: 96.74

COIL: 0.9246

CONS_SCORE: 0.3376

DSS_SCORE: 0.792

HELIX: 0.0166

FCONS_SCORE: 1.0008

RIG_SCORE: 0.6213

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2483P	TCGA-19-5956	GBM	TCGA	VQTTT	DEG_SPOP_SBC_1	0.0556
p.T2483P	DO13863	GBM	ICGC	VQTTT	DEG_SPOP_SBC_1	0.0556
p.E2499K	TCGA-FD-A5BZ	BLCA	TCGA	VQTTT	DEG_SPOP_SBC_1	0.2778
p.E2499K	DO44052	BLCA	ICGC	VQTTT	DEG_SPOP_SBC_1	0.2778
p.H2484Y	TCGA-GC-A3RB	BLCA	TCGA	VQTTT	DEG_SPOP_SBC_1	0.0833
p.H2484Y	DO530	BLCA	ICGC	VQTTT	DEG_SPOP_SBC_1	0.0833
p.A2495G	SIDM00835	Colorectal Carcinoma	GDSC	VQTTT	DEG_SPOP_SBC_1	0.754
p.A2495G	ACH-000489	Colon/Colorectal Cancer	CCLE	VQTTT	DEG_SPOP_SBC_1	0.754
p.A2495G	SW1116	large_intestine	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.754
p.M2502V	EN	endometrium	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.1944
p.K2501T	NCI-H1688	lung	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P56159	GDNF family receptor alpha-1	DEG_SPOP_SBC_1	360:364	VQTTT	SPOP	0.7588	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4299:4303	VQTTT	SPOP	0.5511	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2493:2497	VQTTT	SPOP	0.9806	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	599:603	VQTTT	SPOP	0.8383	More...
Q9UBX8	Beta-1,4-galactosyltransferase 6	DEG_SPOP_SBC_1	90:94	VQTTT	SPOP	0.6336	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons