DegronMD

Uniprot ID: P56159

Source protein: GDNF family receptor alpha-1

Source gene: GFRA1

Class: DEG_SPOP_SBC_1

Location: 360:364

E3 ligase: SPOP

DEGRON score: 0.7588

ASA_SCORE: 92.46

COIL: 0.914

CONS_SCORE: 0.3352

DSS_SCORE: 0.3794

HELIX: 0.0222

FCONS_SCORE: 0.8222

RIG_SCORE: 0.793

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R372W	TCGA-67-4679	LUAD	TCGA	VQTTT	DEG_SPOP_SBC_1	0.1111
p.R372W	TCGA-D5-6529	COAD	TCGA	VQTTT	DEG_SPOP_SBC_1	0.1111
p.K374T	TCGA-AG-A008	READ	TCGA	VQTTT	DEG_SPOP_SBC_1	0.1667
p.Q361H	TCGA-AP-A1DV	UCEC	TCGA	VQTTT	DEG_SPOP_SBC_1	0.647
p.K374N	TCGA-AZ-4315	COAD	TCGA	VQTTT	DEG_SPOP_SBC_1	0.1667
p.D350N	TCGA-BR-8680	STAD	TCGA	VQTTT	DEG_SPOP_SBC_1	0.0556
p.D350N	TCGA-ND-A4WC	UCS	TCGA	VQTTT	DEG_SPOP_SBC_1	0.0556
p.D350N	DO47769	STAD	ICGC	VQTTT	DEG_SPOP_SBC_1	0.0556
p.D350G	TCGA-D8-A147	BRCA	TCGA	VQTTT	DEG_SPOP_SBC_1	0.0556
p.T367S	TCGA-D9-A1JW	SKCM	TCGA	VQTTT	DEG_SPOP_SBC_1	0.25
p.L371I	TCGA-EE-A2M7	SKCM	TCGA	VQTTT	DEG_SPOP_SBC_1	0.1389
p.L371I	DO37847	SKCM	ICGC	VQTTT	DEG_SPOP_SBC_1	0.1389
p.D350Y	TCGA-EO-A3AV	UCEC	TCGA	VQTTT	DEG_SPOP_SBC_1	0.0556
p.D350Y	DO52412	UCEC	ICGC	VQTTT	DEG_SPOP_SBC_1	0.0556
p.D350Y	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	VQTTT	DEG_SPOP_SBC_1	0.0556
p.D350Y	ACH-000912	Lung Cancer	CCLE	VQTTT	DEG_SPOP_SBC_1	0.0556
p.T352N	TCGA-J1-A4AH	LUSC	TCGA	VQTTT	DEG_SPOP_SBC_1	0.1111
p.T366N	DO229034	LICA	ICGC	VQTTT	DEG_SPOP_SBC_1	0.2778
p.T366N	SIDM00908	Non-Cancerous	GDSC	VQTTT	DEG_SPOP_SBC_1	0.2778
p.T366N	ACH-002380	Non-Cancerous	CCLE	VQTTT	DEG_SPOP_SBC_1	0.2778
p.P356Q	DO229009	LICA	ICGC	VQTTT	DEG_SPOP_SBC_1	0.2222
p.R372Q	SIDM00985	Burkitt's Lymphoma	GDSC	VQTTT	DEG_SPOP_SBC_1	0.1111
p.R372Q	ACH-000245	Lymphoma	CCLE	VQTTT	DEG_SPOP_SBC_1	0.1111
p.R372Q	BL-41	haematopoietic_and_lymphoid_tissue	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.1111
p.T364S	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	VQTTT	DEG_SPOP_SBC_1	0.6005
p.T364S	ACH-000521	Lung Cancer	CCLE	VQTTT	DEG_SPOP_SBC_1	0.6005
p.T364S	NCI-H2030	lung	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.6005
p.P359Q	SIDM00501	Oral Cavity Carcinoma	GDSC	VQTTT	DEG_SPOP_SBC_1	0.3056
p.P359Q	ACH-001332	Head and Neck Cancer	CCLE	VQTTT	DEG_SPOP_SBC_1	0.3056
p.P359Q	BICR78	upper_aerodigestive_tract	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.3056
p.T369A	ACH-000499	Bone Cancer	CCLE	VQTTT	DEG_SPOP_SBC_1	0.1944
p.L371R	ACH-000831	Endometrial/Uterine Cancer	CCLE	VQTTT	DEG_SPOP_SBC_1	0.1389
p.R367Q	BL-41	haematopoietic_and_lymphoid_tissue	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.25
p.P354Q	BICR78	upper_aerodigestive_tract	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.1667
p.T359S	NCI-H2030	lung	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P56159	GDNF family receptor alpha-1	DEG_SPOP_SBC_1	360:364	VQTTT	SPOP	0.7588	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4299:4303	VQTTT	SPOP	0.5511	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2493:2497	VQTTT	SPOP	0.9806	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	599:603	VQTTT	SPOP	0.8383	More...
Q9UBX8	Beta-1,4-galactosyltransferase 6	DEG_SPOP_SBC_1	90:94	VQTTT	SPOP	0.6336	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VQTTT

Degron related mutations and impact score

Drug responses associated with GFRA1 mutations

All proteins holding degron of VQTTT