DegronMD

Uniprot ID: Q6ZS17

Source protein: Rho family-interacting cell polarization regulator 1

Source gene: RIPOR1

Class: DEG_SPOP_SBC_1

Location: 599:603

E3 ligase: SPOP

DEGRON score: 0.8383

ASA_SCORE: 105.72

COIL: 0.964

CONS_SCORE: 0.2893

DSS_SCORE: 0.6723

HELIX: 0.0134

FCONS_SCORE: 1.0138

RIG_SCORE: 0.6833

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T603S	SIDM00886	B-Cell Non-Hodgkin's Lymphoma	GDSC	VQTTT	DEG_SPOP_SBC_1	0.6005
p.T603S	DB	haematopoietic_and_lymphoid_tissue	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.6005
p.I612T	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	VQTTT	DEG_SPOP_SBC_1	0.0833
p.I612T	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.0833
p.T613A	SNU-1040	large_intestine	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.0556
p.T597S	DB	haematopoietic_and_lymphoid_tissue	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.2778
p.T603A	SNU-1040	large_intestine	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.7139
p.I606T	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.25
p.I596T	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.25
p.T599A	SNU-1040	large_intestine	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.7139
p.I592T	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P56159	GDNF family receptor alpha-1	DEG_SPOP_SBC_1	360:364	VQTTT	SPOP	0.7588	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4299:4303	VQTTT	SPOP	0.5511	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2493:2497	VQTTT	SPOP	0.9806	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	599:603	VQTTT	SPOP	0.8383	More...
Q9UBX8	Beta-1,4-galactosyltransferase 6	DEG_SPOP_SBC_1	90:94	VQTTT	SPOP	0.6336	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons