DegronMD - P56159(GFRA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R372W	TCGA-67-4679	LUAD	TCGA	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1111
p.R372W	TCGA-D5-6529	COAD	TCGA	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1111
p.K374T	TCGA-AG-A008	READ	TCGA	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation substituting flanking lysine	0.1667
p.Q361H	TCGA-AP-A1DV	UCEC	TCGA	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation altering degron motif	0.647
p.K374N	TCGA-AZ-4315	COAD	TCGA	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation substituting flanking lysine	0.1667
p.D350N	TCGA-BR-8680	STAD	TCGA	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.0556
p.D350N	TCGA-ND-A4WC	UCS	TCGA	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.0556
p.D350N	DO47769	STAD	ICGC	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.0556
p.D350G	TCGA-D8-A147	BRCA	TCGA	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.0556
p.T367S	TCGA-D9-A1JW	SKCM	TCGA	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.25
p.L371I	TCGA-EE-A2M7	SKCM	TCGA	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1389
p.L371I	DO37847	SKCM	ICGC	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1389
p.D350Y	TCGA-EO-A3AV	UCEC	TCGA	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.0556
p.D350Y	DO52412	UCEC	ICGC	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.0556
p.D350Y	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.0556
p.D350Y	ACH-000912	Lung Cancer	CCLE	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.0556
p.T352N	TCGA-J1-A4AH	LUSC	TCGA	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1111
p.T366N	DO229034	LICA	ICGC	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.2778
p.T366N	SIDM00908	Non-Cancerous	GDSC	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.2778
p.T366N	ACH-002380	Non-Cancerous	CCLE	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.2778
p.P356Q	DO229009	LICA	ICGC	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.2222
p.R372Q	SIDM00985	Burkitt's Lymphoma	GDSC	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1111
p.R372Q	ACH-000245	Lymphoma	CCLE	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1111
p.R372Q	BL-41	haematopoietic and lymphoid tissue	COSMIC	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1111
p.T364S	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation altering degron motif	0.6005
p.T364S	ACH-000521	Lung Cancer	CCLE	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation altering degron motif	0.6005
p.T364S	NCI-H2030	lung	COSMIC	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation altering degron motif	0.6005
p.P359Q	SIDM00501	Oral Cavity Carcinoma	GDSC	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.3056
p.P359Q	ACH-001332	Head and Neck Cancer	CCLE	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.3056
p.P359Q	BICR78	upper aerodigestive tract	COSMIC	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.3056
p.T369A	ACH-000499	Bone Cancer	CCLE	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1944
p.L371R	ACH-000831	Endometrial/Uterine Cancer	CCLE	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1389
p.R367Q	BL-41	haematopoietic and lymphoid tissue	COSMIC	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.25
p.P354Q	BICR78	upper aerodigestive tract	COSMIC	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.1667
p.T359S	NCI-H2030	lung	COSMIC	VQTTT	DEG_SPOP_SBC_1	360:364	Mutation rewiring degron network	0.3056

Kaplan plot for GFRA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GFRA1

UniProt ID: P56159

Entrez ID: 2674

Protein name: GDNF family receptor alpha-1 (GDNF receptor alpha-1) (GDNFR-alpha-1) (GFR-alpha-1) (RET ligand 1) (TGF-beta-related neurotrophic factor receptor 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GFRA1 in