DegronMD

Uniprot ID: Q9UBX8

Source protein: Beta-1,4-galactosyltransferase 6

Source gene: B4GALT6

Class: DEG_SPOP_SBC_1

Location: 90:94

E3 ligase: SPOP

DEGRON score: 0.6336

ASA_SCORE: 76.34

COIL: 0.6192

CONS_SCORE: 0.3215

DSS_SCORE: 0.3766

HELIX: 0.0368

FCONS_SCORE: 1.0066

RIG_SCORE: 0.8327

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S85A	TCGA-06-0190	GBM	TCGA	VQTTT	DEG_SPOP_SBC_1	0.1944
p.T94M	DO233731	GACA	ICGC	VQTTT	DEG_SPOP_SBC_1	0.7423
p.T94M	SIDM01126	Small Cell Lung Carcinoma	GDSC	VQTTT	DEG_SPOP_SBC_1	0.7423
p.T94M	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	VQTTT	DEG_SPOP_SBC_1	0.7423
p.T94M	NCI-H64	lung	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.7423
p.T94M	JEKO-1	haematopoietic_and_lymphoid_tissue	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.7423
p.T101R	SIDM00689	B-Lymphoblastic Leukemia	GDSC	VQTTT	DEG_SPOP_SBC_1	0.1389
p.T101R	JM1	haematopoietic_and_lymphoid_tissue	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.1389
p.T92I	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	VQTTT	DEG_SPOP_SBC_1	0.7078
p.T92I	SU-DHL-8	NS	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.7078
p.D87H	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	VQTTT	DEG_SPOP_SBC_1	0.25
p.D87H	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.25
p.P104S	SIDM00217	Colorectal Carcinoma	GDSC	VQTTT	DEG_SPOP_SBC_1	0.0556
p.P104S	SNU-1040	large_intestine	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.0556
p.P97L	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	VQTTT	DEG_SPOP_SBC_1	0.25
p.L80F	ACH-001550	Skin Cancer	CCLE	VQTTT	DEG_SPOP_SBC_1	0.0556
p.L80F	MCC13	skin	COSMIC	VQTTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P56159	GDNF family receptor alpha-1	DEG_SPOP_SBC_1	360:364	VQTTT	SPOP	0.7588	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4299:4303	VQTTT	SPOP	0.5511	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2493:2497	VQTTT	SPOP	0.9806	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	599:603	VQTTT	SPOP	0.8383	More...
Q9UBX8	Beta-1,4-galactosyltransferase 6	DEG_SPOP_SBC_1	90:94	VQTTT	SPOP	0.6336	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons