DegronMD

Uniprot ID: P35125

Source protein: Ubiquitin carboxyl-terminal hydrolase 6

Source gene: USP6

Class: DEG_APCC_DBOX_1

Location: 894:902

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.778

ASA_SCORE: 61.4667

COIL: 0.7503

CONS_SCORE: 0.3976

DSS_SCORE: 0.1481

HELIX: 0.1349

FCONS_SCORE: 1.2895

RIG_SCORE: 0.7729

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G900R	TCGA-BF-A1PZ	SKCM	TCGA	NRPSLFGMP	DEG_APCC_DBOX_1	0.6457
p.G900R	DO50279	SKCM	ICGC	NRPSLFGMP	DEG_APCC_DBOX_1	0.6457
p.T911I	TCGA-DA-A95X	SKCM	TCGA	NRPSLFGMP	DEG_APCC_DBOX_1	0.0833
p.T911I	DO219480	SKCM	ICGC	NRPSLFGMP	DEG_APCC_DBOX_1	0.0833
p.R895C	TCGA-ER-A19F	SKCM	TCGA	NRPSLFGMP	DEG_APCC_DBOX_1	0.8301
p.R895C	DO37679	SKCM	ICGC	NRPSLFGMP	DEG_APCC_DBOX_1	0.8301
p.R895C	SIDM00425	Ovarian Carcinoma	GDSC	NRPSLFGMP	DEG_APCC_DBOX_1	0.8301
p.R895C	SIDM00986	Head and Neck Carcinoma	GDSC	NRPSLFGMP	DEG_APCC_DBOX_1	0.8301
p.R895C	BHY	upper_aerodigestive_tract	COSMIC	NRPSLFGMP	DEG_APCC_DBOX_1	0.8301
p.R895C	OVTOKO	ovary	COSMIC	NRPSLFGMP	DEG_APCC_DBOX_1	0.8301
p.R912Q	DO229016	COCA	ICGC	NRPSLFGMP	DEG_APCC_DBOX_1	0.0556
p.R912Q	DO229003	COCA	ICGC	NRPSLFGMP	DEG_APCC_DBOX_1	0.0556
p.R912Q	DO230993	LUSC	ICGC	NRPSLFGMP	DEG_APCC_DBOX_1	0.0556
p.R912Q	DO230990	LUSC	ICGC	NRPSLFGMP	DEG_APCC_DBOX_1	0.0556
p.R912Q	DO231049	LUSC	ICGC	NRPSLFGMP	DEG_APCC_DBOX_1	0.0556
p.L886P	SIDM01608	Endometrial Carcinoma	GDSC	NRPSLFGMP	DEG_APCC_DBOX_1	0.1111
p.L886P	ACH-000990	Endometrial/Uterine Cancer	CCLE	NRPSLFGMP	DEG_APCC_DBOX_1	0.1111
p.V909L	SIDM01766	Chondrosarcoma	GDSC	NRPSLFGMP	DEG_APCC_DBOX_1	0.1389
p.V909L	ACH-000418	Bone Cancer	CCLE	NRPSLFGMP	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35125	Ubiquitin carboxyl-terminal hydrolase 6	DEG_APCC_DBOX_1	894:902	NRPSLFGMP	APC,CDC20,FZR1	0.778	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons