DegronMD

Uniprot ID: Q9C040

Source protein: Tripartite motif-containing protein 2

Source gene: TRIM2

Class: DEG_APCC_KENBOX_2

Location: 463:467

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6409

ASA_SCORE: 67.54

COIL: 0.4664

CONS_SCORE: 0.2891

DSS_SCORE: 0.4877

HELIX: 0.0158

FCONS_SCORE: 0.9402

RIG_SCORE: 0.7069

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K474N	TCGA-85-8277	LUSC	TCGA	RKENP	DEG_APCC_KENBOX_2	0.1389
p.V465A	TCGA-AY-6197	COAD	TCGA	RKENP	DEG_APCC_KENBOX_2	0.6936
p.P468L	TCGA-BT-A42B	BLCA	TCGA	RKENP	DEG_APCC_KENBOX_2	0.3056
p.G469E	TCGA-D3-A2JH	SKCM	TCGA	RKENP	DEG_APCC_KENBOX_2	0.2778
p.G469V	TCGA-X9-A973	SARC	TCGA	RKENP	DEG_APCC_KENBOX_2	0.2778
p.D471V	DO9956	COAD	ICGC	RKENP	DEG_APCC_KENBOX_2	0.2222
p.E469K	DO222884	COCA	ICGC	RKENP	DEG_APCC_KENBOX_2	0.2778
p.E469K	DO222816	COCA	ICGC	RKENP	DEG_APCC_KENBOX_2	0.2778
p.E469K	DO41488	UCEC	ICGC	RKENP	DEG_APCC_KENBOX_2	0.2778
p.M457I	DO229009	LICA	ICGC	RKENP	DEG_APCC_KENBOX_2	0.1667
p.A455S	DO25967	LUAD	ICGC	RKENP	DEG_APCC_KENBOX_2	0.1111
p.A455S	ACH-002145	Lung Cancer	CCLE	RKENP	DEG_APCC_KENBOX_2	0.1111
p.A455S	IST-SL2	lung	COSMIC	RKENP	DEG_APCC_KENBOX_2	0.1111
p.P467S	DO222843	MELA	ICGC	RKENP	DEG_APCC_KENBOX_2	0.5641
p.A455T	DO232761	PBCA	ICGC	RKENP	DEG_APCC_KENBOX_2	0.1111
p.R453K	DO218900	SKCA	ICGC	RKENP	DEG_APCC_KENBOX_2	0.0556
p.P467L	DO51299	SKCM	ICGC	RKENP	DEG_APCC_KENBOX_2	0.6471
p.D471N	DO41572	UCEC	ICGC	RKENP	DEG_APCC_KENBOX_2	0.2222
p.R453I	DO41542	UCEC	ICGC	RKENP	DEG_APCC_KENBOX_2	0.0556
p.V461M	SIDM01943	Colorectal Carcinoma	GDSC	RKENP	DEG_APCC_KENBOX_2	0.2778
p.R464H	SIDM00449	B-Lymphoblastic Leukemia	GDSC	RKENP	DEG_APCC_KENBOX_2	0.8244
p.R464H	SIDM00382	Glioblastoma	GDSC	RKENP	DEG_APCC_KENBOX_2	0.8244
p.R464H	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	RKENP	DEG_APCC_KENBOX_2	0.8244
p.R464H	SF126	central_nervous_system	COSMIC	RKENP	DEG_APCC_KENBOX_2	0.8244
p.T458I	SIDM00333	Endometrial Carcinoma	GDSC	RKENP	DEG_APCC_KENBOX_2	0.1944
p.T458I	MFE-319	endometrium	COSMIC	RKENP	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76080	AN1-type zinc finger protein 5	DEG_APCC_KENBOX_2	199:203	RKENP	APC,CDC20,FZR1	0.5072	More...
Q99708	DNA endonuclease RBBP8	DEG_APCC_KENBOX_2	178:182	RKENP	APC,CDC20,FZR1	0.8804	More...
Q9C040	Tripartite motif-containing protein 2	DEG_APCC_KENBOX_2	463:467	RKENP	APC,CDC20,FZR1	0.6409	More...
Q9P1Y6	PHD and RING finger domain-containing protein 1	DEG_APCC_KENBOX_2	809:813	RKENP	APC,CDC20,FZR1	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RKENP

Degron related mutations and impact score

Drug responses associated with TRIM2 mutations

All proteins holding degron of RKENP