DegronMD - Q9C040(TRIM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K474N	TCGA-85-8277	LUSC	TCGA	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.1389
p.R363Q	TCGA-AG-A002	READ	TCGA	LSTPDGS	DEG_SCF_FBW7_1	369:375	Mutation rewiring degron network	0.1667
p.V373I	TCGA-AX-A2HA	UCEC	TCGA	LSTPDGS	DEG_SCF_FBW7_1	369:375	Mutation altering degron motif	0.7076
p.V465A	TCGA-AY-6197	COAD	TCGA	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation altering degron motif	0.6936
p.P468L	TCGA-BT-A42B	BLCA	TCGA	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.3056
p.G469E	TCGA-D3-A2JH	SKCM	TCGA	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.2778
p.G469V	TCGA-X9-A973	SARC	TCGA	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.2778
p.E360K	TCGA-XK-AAIW	PRAD	TCGA	LSTPDGS	DEG_SCF_FBW7_1	369:375	Mutation rewiring degron network	0.0833
p.E368K	DO9002	COAD	ICGC	LSTPDGS	DEG_SCF_FBW7_1	369:375	Mutation rewiring degron network	0.3056
p.D471V	DO9956	COAD	ICGC	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.2222
p.D373N	DO9956	COAD	ICGC	LSTPDGS	DEG_SCF_FBW7_1	369:375	Mutation altering degron motif	0.5821
p.D373N	ACH-000985	Colon/Colorectal Cancer	CCLE	LSTPDGS	DEG_SCF_FBW7_1	369:375	Mutation altering degron motif	0.5821
p.E469K	DO222884	COCA	ICGC	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.2778
p.E469K	DO222816	COCA	ICGC	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.2778
p.E469K	DO41488	UCEC	ICGC	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.2778
p.M457I	DO229009	LICA	ICGC	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.1667
p.A455S	DO25967	LUAD	ICGC	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.1111
p.A455S	ACH-002145	Lung Cancer	CCLE	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.1111
p.A455S	IST-SL2	lung	COSMIC	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.1111
p.G374W	DO45450	LUSC	ICGC	LSTPDGS	DEG_SCF_FBW7_1	369:375	Mutation altering degron motif	0.6714
p.P467S	DO222843	MELA	ICGC	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation altering degron motif	0.5641
p.A363T	DO46657	PAAD	ICGC	LSTPDGS	DEG_SCF_FBW7_1	369:375	Mutation rewiring degron network	0.1667
p.A455T	DO232761	PBCA	ICGC	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.1111
p.R453K	DO218900	SKCA	ICGC	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.0556
p.P467L	DO51299	SKCM	ICGC	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation altering degron motif	0.6471
p.A367V	DO47873	STAD	ICGC	LSTPDGS	DEG_SCF_FBW7_1	369:375	Mutation rewiring degron network	0.2778
p.G374R	DO222328	STAD	ICGC	LSTPDGS	DEG_SCF_FBW7_1	369:375	Mutation altering degron motif	0.6457
p.D471N	DO41572	UCEC	ICGC	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.2222
p.R453I	DO41542	UCEC	ICGC	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.0556
p.V376M	DO41361	UCEC	ICGC	LSTPDGS	DEG_SCF_FBW7_1	369:375	Mutation rewiring degron network	0.3056
p.V461M	SIDM01943	Colorectal Carcinoma	GDSC	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.2778
p.T365S	SIDM00334	Endometrial Carcinoma	GDSC	LSTPDGS	DEG_SCF_FBW7_1	369:375	Mutation rewiring degron network	0.2222
p.R464H	SIDM00449	B-Lymphoblastic Leukemia	GDSC	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation altering degron motif	0.8244
p.R464H	SIDM00382	Glioblastoma	GDSC	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation altering degron motif	0.8244
p.R464H	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation altering degron motif	0.8244
p.R464H	SF126	central nervous system	COSMIC	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation altering degron motif	0.8244
p.T458I	SIDM00333	Endometrial Carcinoma	GDSC	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.1944
p.T458I	MFE-319	endometrium	COSMIC	RKENP	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.1944
p.G382C	SIDM01387	Small Cell Lung Carcinoma	GDSC	LSTPDGS	DEG_SCF_FBW7_1	369:375	Mutation rewiring degron network	0.1389

Kaplan plot for TRIM2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRIM2

UniProt ID: Q9C040

Entrez ID: 23321

Protein name: Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) (RING-type E3 ubiquitin transferase TRIM2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRIM2 in