DegronMD

Uniprot ID: Q9C040

Source protein: Tripartite motif-containing protein 2

Source gene: TRIM2

Class: DEG_SCF_FBW7_1

Location: 369:375

E3 ligase: FBXW7

DEGRON score: 0.9833

ASA_SCORE: 44.8286

COIL: 0.7173

CONS_SCORE: 0.3472

DSS_SCORE: 0.3756

HELIX: 0.0066

FCONS_SCORE: 1.0098

RIG_SCORE: 0.7268

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R363Q	TCGA-AG-A002	READ	TCGA	LSTPDGS	DEG_SCF_FBW7_1	0.1667
p.V373I	TCGA-AX-A2HA	UCEC	TCGA	LSTPDGS	DEG_SCF_FBW7_1	0.7076
p.E360K	TCGA-XK-AAIW	PRAD	TCGA	LSTPDGS	DEG_SCF_FBW7_1	0.0833
p.E368K	DO9002	COAD	ICGC	LSTPDGS	DEG_SCF_FBW7_1	0.3056
p.D373N	DO9956	COAD	ICGC	LSTPDGS	DEG_SCF_FBW7_1	0.5821
p.D373N	ACH-000985	Colon/Colorectal Cancer	CCLE	LSTPDGS	DEG_SCF_FBW7_1	0.5821
p.G374W	DO45450	LUSC	ICGC	LSTPDGS	DEG_SCF_FBW7_1	0.6714
p.A363T	DO46657	PAAD	ICGC	LSTPDGS	DEG_SCF_FBW7_1	0.1667
p.A367V	DO47873	STAD	ICGC	LSTPDGS	DEG_SCF_FBW7_1	0.2778
p.G374R	DO222328	STAD	ICGC	LSTPDGS	DEG_SCF_FBW7_1	0.6457
p.V376M	DO41361	UCEC	ICGC	LSTPDGS	DEG_SCF_FBW7_1	0.3056
p.T365S	SIDM00334	Endometrial Carcinoma	GDSC	LSTPDGS	DEG_SCF_FBW7_1	0.2222
p.G382C	SIDM01387	Small Cell Lung Carcinoma	GDSC	LSTPDGS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C040	Tripartite motif-containing protein 2	DEG_SCF_FBW7_1	369:375	LSTPDGS	FBXW7	0.9833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons