DegronMD

Uniprot ID: Q9P1Y6

Source protein: PHD and RING finger domain-containing protein 1

Source gene: PHRF1

Class: DEG_SCF_TRCP1_1

Location: 41:46

E3 ligase: BTRC

DEGRON score: 0.723

ASA_SCORE: 88.0667

COIL: 0.932

CONS_SCORE: 0.4083

DSS_SCORE: 0.9104

HELIX: 0.0527

FCONS_SCORE: 0.9691

RIG_SCORE: 0.453

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S38N	TCGA-AX-A1CE	UCEC	TCGA	DSGDDS	DEG_SCF_TRCP1_1	0.25
p.D44N	TCGA-BK-A6W3	UCEC	TCGA	DSGDDS	DEG_SCF_TRCP1_1	0.5821
p.D41E	TCGA-D1-A1NZ	UCEC	TCGA	DSGDDS	DEG_SCF_TRCP1_1	0.6758
p.G53V	TCGA-F4-6856	COAD	TCGA	DSGDDS	DEG_SCF_TRCP1_1	0.1389
p.G52V	DO9114	COAD	ICGC	DSGDDS	DEG_SCF_TRCP1_1	0.1667
p.E55K	DO233823	GACA	ICGC	DSGDDS	DEG_SCF_TRCP1_1	0.0833
p.D54G	DO38404	STAD	ICGC	DSGDDS	DEG_SCF_TRCP1_1	0.1111
p.D40N	DO50076	UCEC	ICGC	DSGDDS	DEG_SCF_TRCP1_1	0.3056
p.S34N	DO42280	UCEC	ICGC	DSGDDS	DEG_SCF_TRCP1_1	0.1389
p.D40E	DO41536	UCEC	ICGC	DSGDDS	DEG_SCF_TRCP1_1	0.3056
p.V36M	SIDM00370	T-Lymphoblastic Leukemia	GDSC	DSGDDS	DEG_SCF_TRCP1_1	0.1944
p.V36M	ACH-000197	Leukemia	CCLE	DSGDDS	DEG_SCF_TRCP1_1	0.1944
p.V36M	TALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGDDS	DEG_SCF_TRCP1_1	0.1944
p.G43R	SIDM01343	Gastric Carcinoma	GDSC	DSGDDS	DEG_SCF_TRCP1_1	0.7568
p.G43R	ACH-000764	Gastric Cancer	CCLE	DSGDDS	DEG_SCF_TRCP1_1	0.7568
p.G40V	ACH-000512	Myeloma	CCLE	DSGDDS	DEG_SCF_TRCP1_1	0.3056
p.V32M	TALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGDDS	DEG_SCF_TRCP1_1	0.0833
p.V35M	TALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGDDS	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P1Y6	PHD and RING finger domain-containing protein 1	DEG_SCF_TRCP1_1	41:46	DSGDDS	BTRC	0.723	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons