DegronMD

Uniprot ID: O76080

Source protein: AN1-type zinc finger protein 5

Source gene: ZFAND5

Class: DEG_SCF_FBW7_2

Location: 112:118

E3 ligase: FBXW7

DEGRON score: 0.9927

ASA_SCORE: 100.6714

COIL: 0.8586

CONS_SCORE: 0.3683

DSS_SCORE: 0.645

HELIX: 0.0521

FCONS_SCORE: 1.3091

RIG_SCORE: 0.683

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S105I	TCGA-A5-A1OF	UCEC	TCGA	ITTPKTE	DEG_SCF_FBW7_2	0.1389
p.S105I	DO42568	UCEC	ICGC	ITTPKTE	DEG_SCF_FBW7_2	0.1389
p.K111N	TCGA-F5-6814	READ	TCGA	ITTPKTE	DEG_SCF_FBW7_2	0.3056
p.K111N	DO36556	READ	ICGC	ITTPKTE	DEG_SCF_FBW7_2	0.3056
p.S120L	TCGA-GM-A2DO	BRCA	TCGA	ITTPKTE	DEG_SCF_FBW7_2	0.2778
p.S120L	DO2037	BRCA	ICGC	ITTPKTE	DEG_SCF_FBW7_2	0.2778
p.S128I	TCGA-IB-7651	PAAD	TCGA	ITTPKTE	DEG_SCF_FBW7_2	0.5
p.S128I	DO46657	PAAD	ICGC	ITTPKTE	DEG_SCF_FBW7_2	0.5
p.P127H	DO229045	LICA	ICGC	ITTPKTE	DEG_SCF_FBW7_2	0.0833
p.T114I	ACH-001322	Sarcoma	CCLE	ITTPKTE	DEG_SCF_FBW7_2	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76080	AN1-type zinc finger protein 5	DEG_SCF_FBW7_2	112:118	ITTPKTE	FBXW7	0.9927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons