DegronMD

Uniprot ID: P15884

Source protein: Transcription factor 4

Source gene: TCF4

Class: DEG_SCF_FBW7_1

Location: 345:351

E3 ligase: FBXW7

DEGRON score: 0.9967

ASA_SCORE: 66.5714

COIL: 0.9584

CONS_SCORE: 0.4811

DSS_SCORE: 0.6018

HELIX: 0.013

FCONS_SCORE: 1.0424

RIG_SCORE: 0.5686

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L344F	TCGA-75-6214	LUAD	TCGA	PSTPVGS	DEG_SCF_FBW7_1	0.3056
p.S347C	TCGA-A2-A0CL	BRCA	TCGA	PSTPVGS	DEG_SCF_FBW7_1	0.7541
p.Q337H	TCGA-AX-A0J0	UCEC	TCGA	PSTPVGS	DEG_SCF_FBW7_1	0.1111
p.S354N	TCGA-AX-A0J1	UCEC	TCGA	PSTPVGS	DEG_SCF_FBW7_1	0.25
p.S354N	SIDM00373	Endometrial Carcinoma	GDSC	PSTPVGS	DEG_SCF_FBW7_1	0.25
p.S354N	SNG-M	endometrium	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	0.25
p.P348S	DO44042	BLCA	ICGC	PSTPVGS	DEG_SCF_FBW7_1	0.6752
p.S340R	DO6308	CESC	ICGC	PSTPVGS	DEG_SCF_FBW7_1	0.1944
p.T359K	DO228974	LICA	ICGC	PSTPVGS	DEG_SCF_FBW7_1	0.1111
p.N344K	DO229028	LICA	ICGC	PSTPVGS	DEG_SCF_FBW7_1	0.3056
p.N339K	DO229038	LICA	ICGC	PSTPVGS	DEG_SCF_FBW7_1	0.1667
p.S354P	DO52243	LIHC	ICGC	PSTPVGS	DEG_SCF_FBW7_1	0.25
p.N344S	DO45452	LUSC	ICGC	PSTPVGS	DEG_SCF_FBW7_1	0.3056
p.S343L	DO50288	SKCM	ICGC	PSTPVGS	DEG_SCF_FBW7_1	0.2778
p.S342L	DO47563	SKCM	ICGC	PSTPVGS	DEG_SCF_FBW7_1	0.25
p.G342E	SIDM00120	Prostate Carcinoma	GDSC	PSTPVGS	DEG_SCF_FBW7_1	0.25
p.S353T	SIDM00225	Melanoma	GDSC	PSTPVGS	DEG_SCF_FBW7_1	0.2778
p.S353T	IST-MEL1	skin	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	0.2778
p.H356R	CCK-81	large_intestine	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	0.1944
p.P352S	SK-MEL-2	skin	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	0.3056
p.N343I	NCI-H211	lung	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	0.2778
p.G358R	NCI-H661	lung	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	0.1389
p.H338R	CCK-81	large_intestine	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	0.1389
p.H342Q	RKO	large_intestine	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	0.25
p.P358S	SK-MEL-2	skin	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	0.1389
p.N361D	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	0.0556
p.R349L	DU-145	prostate	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	0.8428
p.H355Q	RKO	large_intestine	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	0.2222
p.N356I	NCI-H211	lung	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	0.1944
p.D356V	NCC021	kidney	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	0.1944
p.P350S	SK-MEL-2	skin	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	0.6752
p.R360W	HCT-15	large_intestine	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	0.0833
p.R345L	DU-145	prostate	COSMIC	PSTPVGS	DEG_SCF_FBW7_1	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15884	Transcription factor 4	DEG_SCF_FBW7_1	345:351	PSTPVGS	FBXW7	0.9967	More...
P15923	Transcription factor E2-alpha	DEG_SCF_FBW7_1	353:359	PSTPVGS	FBXW7	0.9991	More...
Q99081	Transcription factor 12	DEG_SCF_FBW7_1	360:366	PSTPVGS	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTPVGS

Degron related mutations and impact score

Drug responses associated with TCF4 mutations

All proteins holding degron of PSTPVGS