DegronMD

Uniprot ID: Q8NI08

Source protein: Nuclear receptor coactivator 7

Source gene: NCOA7

Class: DEG_SIAH_1

Location: 173:181

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9975

ASA_SCORE: 74.2111

COIL: 0.9446

CONS_SCORE: 0.3651

DSS_SCORE: 0.5531

HELIX: 0.0347

FCONS_SCORE: 1.0977

RIG_SCORE: 0.5365

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P191H	TCGA-AP-A0LM	UCEC	TCGA	SPGATVSPS	DEG_SIAH_1	0.0556
p.P191H	DO43306	UCEC	ICGC	SPGATVSPS	DEG_SIAH_1	0.0556
p.R168S	DO229037	LICA	ICGC	SPGATVSPS	DEG_SIAH_1	0.1944
p.D185N	NCI-H727	lung	COSMIC	SPGATVSPS	DEG_SIAH_1	0.2222
p.M168V	LS-180	large_intestine	COSMIC	SPGATVSPS	DEG_SIAH_1	0.1944
p.R177Q	NCI-H1770	lung	COSMIC	SPGATVSPS	DEG_SIAH_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NI08	Nuclear receptor coactivator 7	DEG_SIAH_1	173:181	SPGATVSPS	SIAH1,SIAH2,SIAH3	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons