DegronMD

Uniprot ID: Q9NS87

Source protein: Kinesin-like protein KIF15

Source gene: KIF15

Class: DEG_APCC_DBOX_1

Location: 1308:1316

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5846

ASA_SCORE: 103.9222

COIL: 0.0061

CONS_SCORE: 0.3472

DSS_SCORE: 0.516

HELIX: 0.9939

FCONS_SCORE: 1.0875

RIG_SCORE: 0.7432

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1325D	TCGA-BR-8361	STAD	TCGA	LRSKLEEMY	DEG_APCC_DBOX_1	0.0833
p.Q1303H	TCGA-BR-8363	STAD	TCGA	LRSKLEEMY	DEG_APCC_DBOX_1	0.1944
p.Q1303K	TCGA-D3-A3C8	SKCM	TCGA	LRSKLEEMY	DEG_APCC_DBOX_1	0.1944
p.M1315L	TCGA-D9-A1JW	SKCM	TCGA	LRSKLEEMY	DEG_APCC_DBOX_1	0.5999
p.M1315L	DO37786	SKCM	ICGC	LRSKLEEMY	DEG_APCC_DBOX_1	0.5999
p.M1315V	TCGA-FI-A2D5	UCEC	TCGA	LRSKLEEMY	DEG_APCC_DBOX_1	0.6097
p.E1314K	TCGA-IR-A3LK	CESC	TCGA	LRSKLEEMY	DEG_APCC_DBOX_1	0.591
p.E1314K	DO44299	CESC	ICGC	LRSKLEEMY	DEG_APCC_DBOX_1	0.591
p.E1320Q	TCGA-IR-A3LK	CESC	TCGA	LRSKLEEMY	DEG_APCC_DBOX_1	0.2222
p.S1299Y	DO223015	ESCA	ICGC	LRSKLEEMY	DEG_APCC_DBOX_1	0.0833
p.E1306V	SIDM01112	Osteosarcoma	GDSC	LRSKLEEMY	DEG_APCC_DBOX_1	0.2778
p.E1306V	ACH-000748	Bone Cancer	CCLE	LRSKLEEMY	DEG_APCC_DBOX_1	0.2778
p.E1306V	SJSA-1	bone	COSMIC	LRSKLEEMY	DEG_APCC_DBOX_1	0.2778
p.T1322A	SIDM00217	Colorectal Carcinoma	GDSC	LRSKLEEMY	DEG_APCC_DBOX_1	0.1667
p.T1322A	ACH-000999	Colon/Colorectal Cancer	CCLE	LRSKLEEMY	DEG_APCC_DBOX_1	0.1667
p.T1322A	SNU-1040	large_intestine	COSMIC	LRSKLEEMY	DEG_APCC_DBOX_1	0.1667
p.S1299F	SIDM00534	Colorectal Carcinoma	GDSC	LRSKLEEMY	DEG_APCC_DBOX_1	0.0833
p.S1299F	ACH-000986	Colon/Colorectal Cancer	CCLE	LRSKLEEMY	DEG_APCC_DBOX_1	0.0833
p.S1299F	HT-115	large_intestine	COSMIC	LRSKLEEMY	DEG_APCC_DBOX_1	0.0833
p.E1317K	ACH-000454	Lung Cancer	CCLE	LRSKLEEMY	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NS87	Kinesin-like protein KIF15	DEG_APCC_DBOX_1	1308:1316	LRSKLEEMY	APC,CDC20,FZR1	0.5846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons