DegronMD

Uniprot ID: Q9NS87

Source protein: Kinesin-like protein KIF15

Source gene: KIF15

Class: LIG_APCC_ABBA_1

Location: 167:172

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5682

ASA_SCORE: 30.6167

COIL: 0.3222

CONS_SCORE: 0.6746

DSS_SCORE: 0.0084

HELIX: 0.0228

FCONS_SCORE: 1.2897

RIG_SCORE: 0.9564

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S159N	TCGA-AP-A059	UCEC	TCGA	IEIYNE	LIG_APCC_ABBA_1	0.1111
p.S159N	DO41361	UCEC	ICGC	IEIYNE	LIG_APCC_ABBA_1	0.1111
p.L161F	TCGA-DI-A1BU	UCEC	TCGA	IEIYNE	LIG_APCC_ABBA_1	0.1667
p.L161F	DO42023	UCEC	ICGC	IEIYNE	LIG_APCC_ABBA_1	0.1667
p.E172K	TCGA-FI-A3PV	UCEC	TCGA	IEIYNE	LIG_APCC_ABBA_1	0.7022
p.E172K	DO48169	UCEC	ICGC	IEIYNE	LIG_APCC_ABBA_1	0.7022
p.L161P	SIDM00082	Melanoma	GDSC	IEIYNE	LIG_APCC_ABBA_1	0.1667
p.L161P	ACH-001190	Skin Cancer	CCLE	IEIYNE	LIG_APCC_ABBA_1	0.1667
p.L161P	SK-MEL-2	skin	COSMIC	IEIYNE	LIG_APCC_ABBA_1	0.1667
p.L177V	ACH-001864	Bile Duct Cancer	CCLE	IEIYNE	LIG_APCC_ABBA_1	0.1944
p.S182L	H2810	pleura	COSMIC	IEIYNE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NS87	Kinesin-like protein KIF15	LIG_APCC_ABBA_1	167:172	IEIYNE	APC,CDC20,FZR1	0.5682	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons