DegronMD

Uniprot ID: Q8IZQ8

Source protein: Myocardin

Source gene: MYOCD

Class: DEG_SCF_FBW7_1

Location: 893:900

E3 ligase: FBXW7

DEGRON score: 0.9322

ASA_SCORE: 86.6625

COIL: 0.8785

CONS_SCORE: 0.4308

DSS_SCORE: 0.4829

HELIX: 0.0908

FCONS_SCORE: 1.1239

RIG_SCORE: 0.7523

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I904S	TCGA-23-2649	OV	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	0.2222
p.I904S	DO31779	OV	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	0.2222
p.F890L	TCGA-B5-A11N	UCEC	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	0.25
p.F890L	TCGA-EO-A3B0	UCEC	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	0.25
p.F890L	TCGA-EY-A1G8	UCEC	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	0.25
p.F890L	TCGA-EY-A1GI	UCEC	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	0.25
p.F890L	DO219773	UCEC	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	0.25
p.F890L	DO43578	UCEC	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	0.25
p.F890L	DO41211	UCEC	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	0.25
p.F890L	DO41458	UCEC	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	0.25
p.E903K	TCGA-BT-A20V	BLCA	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	0.25
p.E903K	TCGA-CN-4723	HNSC	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	0.25
p.E903K	DO689	BLCA	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	0.25
p.E903K	DO14830	HNSC	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	0.25
p.G885E	TCGA-D9-A6EC	SKCM	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	0.1111
p.G885E	DO50291	SKCM	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	0.1111
p.G885E	SIDM01561	Melanoma	GDSC	LDLTPPNS	DEG_SCF_FBW7_1	0.1111
p.D897Y	TCGA-EO-A3AV	UCEC	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	0.7325
p.D897Y	DO222762	COCA	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	0.7325
p.D897Y	DO52412	UCEC	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	0.7325
p.A901V	TCGA-EY-A215	UCEC	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	0.3056
p.A901V	DO42665	UCEC	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	0.3056
p.L905V	TCGA-W3-A825	SKCM	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	0.1944
p.L905V	DO51272	SKCM	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	0.1944
p.F899L	TCGA-XF-AAMZ	BLCA	TCGA	LDLTPPNS	DEG_SCF_FBW7_1	0.6981
p.F899L	DO219051	BLCA	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	0.6981
p.D884H	DO27905	ORCA	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	0.0833
p.M887I	DO218860	SKCA	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	0.1667
p.D888N	DO227688	SKCA	ICGC	LDLTPPNS	DEG_SCF_FBW7_1	0.1944
p.S905G	ACH-000218	Leukemia	CCLE	LDLTPPNS	DEG_SCF_FBW7_1	0.1944
p.S905G	PL-21	haematopoietic_and_lymphoid_tissue	COSMIC	LDLTPPNS	DEG_SCF_FBW7_1	0.1944
p.M890T	ACH-000957	Colon/Colorectal Cancer	CCLE	LDLTPPNS	DEG_SCF_FBW7_1	0.25
p.M890T	LS-180	large_intestine	COSMIC	LDLTPPNS	DEG_SCF_FBW7_1	0.25
p.L895F	ACH-001353	Pancreatic Cancer	CCLE	LDLTPPNS	DEG_SCF_FBW7_1	0.587
p.T883S	MIA-PaCa-2	pancreas	COSMIC	LDLTPPNS	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LDLTPPNS

Degron related mutations and impact score

Drug responses associated with MYOCD mutations

All proteins holding degron of LDLTPPNS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZQ8	Myocardin	DEG_SCF_FBW7_1	893:900	LDLTPPNS	FBXW7	0.9322	More...