DegronMD

Uniprot ID: Q8IZQ8

Source protein: Myocardin

Source gene: MYOCD

Class: LIG_APCC_ABBA_1

Location: 401:406

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7446

ASA_SCORE: 104.3667

COIL: 0.8328

CONS_SCORE: 0.6293

DSS_SCORE: 0.4365

HELIX: 0.1255

FCONS_SCORE: 1.1569

RIG_SCORE: 0.782

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R400Q	TCGA-12-0619	GBM	TCGA	LRPFQD	LIG_APCC_ABBA_1	0.3056
p.R400Q	DO12898	GBM	ICGC	LRPFQD	LIG_APCC_ABBA_1	0.3056
p.R402Q	TCGA-19-5956	GBM	TCGA	LRPFQD	LIG_APCC_ABBA_1	0.6218
p.R402Q	TCGA-EO-A22U	UCEC	TCGA	LRPFQD	LIG_APCC_ABBA_1	0.6218
p.R402Q	TCGA-VQ-A91K	STAD	TCGA	LRPFQD	LIG_APCC_ABBA_1	0.6218
p.R402Q	DO13863	GBM	ICGC	LRPFQD	LIG_APCC_ABBA_1	0.6218
p.R402Q	DO220862	MELA	ICGC	LRPFQD	LIG_APCC_ABBA_1	0.6218
p.R402Q	DO51785	STAD	ICGC	LRPFQD	LIG_APCC_ABBA_1	0.6218
p.R402Q	DO43755	UCEC	ICGC	LRPFQD	LIG_APCC_ABBA_1	0.6218
p.T395M	TCGA-28-1746	GBM	TCGA	LRPFQD	LIG_APCC_ABBA_1	0.1667
p.T395M	DO13564	GBM	ICGC	LRPFQD	LIG_APCC_ABBA_1	0.1667
p.P413T	TCGA-38-7271	LUAD	TCGA	LRPFQD	LIG_APCC_ABBA_1	0.1389
p.P413T	DO26142	LUAD	ICGC	LRPFQD	LIG_APCC_ABBA_1	0.1389
p.D399E	TCGA-3N-A9WC	SKCM	TCGA	LRPFQD	LIG_APCC_ABBA_1	0.2778
p.D399E	DO51234	SKCM	ICGC	LRPFQD	LIG_APCC_ABBA_1	0.2778
p.G392D	TCGA-AN-A0AK	BRCA	TCGA	LRPFQD	LIG_APCC_ABBA_1	0.0833
p.G392D	DO1608	BRCA	ICGC	LRPFQD	LIG_APCC_ABBA_1	0.0833
p.G416V	TCGA-D3-A3CE	SKCM	TCGA	LRPFQD	LIG_APCC_ABBA_1	0.0556
p.G416V	DO37405	SKCM	ICGC	LRPFQD	LIG_APCC_ABBA_1	0.0556
p.M398I	TCGA-D7-A4Z0	STAD	TCGA	LRPFQD	LIG_APCC_ABBA_1	0.25
p.M398I	DO229459	SKCA	ICGC	LRPFQD	LIG_APCC_ABBA_1	0.25
p.M398I	DO47765	STAD	ICGC	LRPFQD	LIG_APCC_ABBA_1	0.25
p.T393I	TCGA-EE-A2MR	SKCM	TCGA	LRPFQD	LIG_APCC_ABBA_1	0.1111
p.T393I	DO37819	SKCM	ICGC	LRPFQD	LIG_APCC_ABBA_1	0.1111
p.P411Q	TCGA-EE-A3AC	SKCM	TCGA	LRPFQD	LIG_APCC_ABBA_1	0.1944
p.P411Q	DO37631	SKCM	ICGC	LRPFQD	LIG_APCC_ABBA_1	0.1944
p.G416R	TCGA-FR-A726	SKCM	TCGA	LRPFQD	LIG_APCC_ABBA_1	0.0556
p.G416R	DO48665	SKCM	ICGC	LRPFQD	LIG_APCC_ABBA_1	0.0556
p.R400W	TCGA-KK-A7B4	PRAD	TCGA	LRPFQD	LIG_APCC_ABBA_1	0.3056
p.R400W	DO234159	ESAD	ICGC	LRPFQD	LIG_APCC_ABBA_1	0.3056
p.R400W	DO219311	PRAD	ICGC	LRPFQD	LIG_APCC_ABBA_1	0.3056
p.R400W	DO230449	UTCA	ICGC	LRPFQD	LIG_APCC_ABBA_1	0.3056
p.T395A	DO234225	ESAD	ICGC	LRPFQD	LIG_APCC_ABBA_1	0.1667
p.G409C	DO228971	LICA	ICGC	LRPFQD	LIG_APCC_ABBA_1	0.25
p.D406N	SIDM00007	Other Solid Cancers	GDSC	LRPFQD	LIG_APCC_ABBA_1	0.6932
p.D406N	ACH-001550	Skin Cancer	CCLE	LRPFQD	LIG_APCC_ABBA_1	0.6932
p.D406N	MCC13	skin	COSMIC	LRPFQD	LIG_APCC_ABBA_1	0.6932
p.L401I	SIDM00193	Colorectal Carcinoma	GDSC	LRPFQD	LIG_APCC_ABBA_1	0.6063
p.L401I	ACH-000991	Colon/Colorectal Cancer	CCLE	LRPFQD	LIG_APCC_ABBA_1	0.6063
p.L401I	SNU-81	large_intestine	COSMIC	LRPFQD	LIG_APCC_ABBA_1	0.6063
p.D399Y	ACH-000436	Myeloma	CCLE	LRPFQD	LIG_APCC_ABBA_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRPFQD

Degron related mutations and impact score

Drug responses associated with MYOCD mutations

All proteins holding degron of LRPFQD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZQ8	Myocardin	LIG_APCC_ABBA_1	401:406	LRPFQD	APC,CDC20,FZR1	0.7446	More...