DegronMD

Uniprot ID: Q8IZQ8

Source protein: Myocardin

Source gene: MYOCD

Class: DEG_SPOP_SBC_1

Location: 906:910

E3 ligase: SPOP

DEGRON score: 0.987

ASA_SCORE: 75.66

COIL: 0.9178

CONS_SCORE: 0.3982

DSS_SCORE: 0.3421

HELIX: 0.0298

FCONS_SCORE: 0.9456

RIG_SCORE: 0.7266

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I904S	TCGA-23-2649	OV	TCGA	ALTTS	DEG_SPOP_SBC_1	0.2778
p.I904S	DO31779	OV	ICGC	ALTTS	DEG_SPOP_SBC_1	0.2778
p.P906A	TCGA-91-6828	LUAD	TCGA	ALTTS	DEG_SPOP_SBC_1	0.7503
p.P906A	DO26150	LUAD	ICGC	ALTTS	DEG_SPOP_SBC_1	0.7503
p.E903K	TCGA-BT-A20V	BLCA	TCGA	ALTTS	DEG_SPOP_SBC_1	0.25
p.E903K	TCGA-CN-4723	HNSC	TCGA	ALTTS	DEG_SPOP_SBC_1	0.25
p.E903K	DO689	BLCA	ICGC	ALTTS	DEG_SPOP_SBC_1	0.25
p.E903K	DO14830	HNSC	ICGC	ALTTS	DEG_SPOP_SBC_1	0.25
p.S917L	TCGA-D3-A8GQ	SKCM	TCGA	ALTTS	DEG_SPOP_SBC_1	0.1389
p.S917L	TCGA-EE-A2MD	SKCM	TCGA	ALTTS	DEG_SPOP_SBC_1	0.1389
p.S917L	TCGA-ER-A19M	SKCM	TCGA	ALTTS	DEG_SPOP_SBC_1	0.1389
p.S917L	TCGA-W3-AA1R	SKCM	TCGA	ALTTS	DEG_SPOP_SBC_1	0.1389
p.S917L	DO229177	LMS	ICGC	ALTTS	DEG_SPOP_SBC_1	0.1389
p.S917L	DO37851	SKCM	ICGC	ALTTS	DEG_SPOP_SBC_1	0.1389
p.S917L	DO37798	SKCM	ICGC	ALTTS	DEG_SPOP_SBC_1	0.1389
p.S917L	DO51275	SKCM	ICGC	ALTTS	DEG_SPOP_SBC_1	0.1389
p.S917L	DO51246	SKCM	ICGC	ALTTS	DEG_SPOP_SBC_1	0.1389
p.A901V	TCGA-EY-A215	UCEC	TCGA	ALTTS	DEG_SPOP_SBC_1	0.1944
p.A901V	DO42665	UCEC	ICGC	ALTTS	DEG_SPOP_SBC_1	0.1944
p.L905V	TCGA-W3-A825	SKCM	TCGA	ALTTS	DEG_SPOP_SBC_1	0.3056
p.L905V	DO51272	SKCM	ICGC	ALTTS	DEG_SPOP_SBC_1	0.3056
p.T914I	DO48294	ESCA	ICGC	ALTTS	DEG_SPOP_SBC_1	0.2222
p.S919F	DO49075	PACA	ICGC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.L909P	DO36822	READ	ICGC	ALTTS	DEG_SPOP_SBC_1	0.7582
p.G907D	SIDM01608	Endometrial Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.7198
p.S905G	ACH-000218	Leukemia	CCLE	ALTTS	DEG_SPOP_SBC_1	0.3056
p.S905G	PL-21	haematopoietic_and_lymphoid_tissue	COSMIC	ALTTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	3900:3904	ALTTS	SPOP	0.8153	More...
Q5T1M5	FK506-binding protein 15	DEG_SPOP_SBC_1	998:1002	ALTTS	SPOP	0.6317	More...
Q8IZQ8	Myocardin	DEG_SPOP_SBC_1	906:910	ALTTS	SPOP	0.987	More...
Q8N139	ATP-binding cassette sub-family A member 6	DEG_SPOP_SBC_1	1265:1269	ALTTS	SPOP	0.6087	More...
Q8N350	Voltage-dependent calcium channel beta subunit-associated regulatory protein	DEG_SPOP_SBC_1	22:26	ALTTS	SPOP	0.7614	More...
Q9H422	Homeodomain-interacting protein kinase 3	DEG_SPOP_SBC_1	592:596	ALTTS	SPOP	0.9044	More...
Q9Y3R5	Protein dopey-2	DEG_SPOP_SBC_1	1204:1208	ALTTS	SPOP	0.8427	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons