DegronMD

Uniprot ID: Q8N350

Source protein: Voltage-dependent calcium channel beta subunit-associated regulatory protein

Source gene: CBARP

Class: DEG_SPOP_SBC_1

Location: 22:26

E3 ligase: SPOP

DEGRON score: 0.7614

ASA_SCORE: 56.72

COIL: 0.443

CONS_SCORE: 0.3525

DSS_SCORE: 0.4666

HELIX: 0.0464

FCONS_SCORE: 0.9565

RIG_SCORE: 0.8395

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T13I	SIDM00907	Burkitt's Lymphoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0833
p.A30V	SIDM00970	Bladder Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.2222
p.A30V	DSH1	urinary_tract	COSMIC	ALTTS	DEG_SPOP_SBC_1	0.2222
p.T12A	SIDM00150	Colorectal Carcinoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.0556
p.D28Y	SIDM00153	T-Lymphoblastic Leukemia	GDSC	ALTTS	DEG_SPOP_SBC_1	0.2778
p.R33L	SIDM01763	Rhabdomyosarcoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.1389
p.A24V	DSH1	urinary_tract	COSMIC	ALTTS	DEG_SPOP_SBC_1	0.6936
p.I35T	23132-87	stomach	COSMIC	ALTTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	3900:3904	ALTTS	SPOP	0.8153	More...
Q5T1M5	FK506-binding protein 15	DEG_SPOP_SBC_1	998:1002	ALTTS	SPOP	0.6317	More...
Q8IZQ8	Myocardin	DEG_SPOP_SBC_1	906:910	ALTTS	SPOP	0.987	More...
Q8N139	ATP-binding cassette sub-family A member 6	DEG_SPOP_SBC_1	1265:1269	ALTTS	SPOP	0.6087	More...
Q8N350	Voltage-dependent calcium channel beta subunit-associated regulatory protein	DEG_SPOP_SBC_1	22:26	ALTTS	SPOP	0.7614	More...
Q9H422	Homeodomain-interacting protein kinase 3	DEG_SPOP_SBC_1	592:596	ALTTS	SPOP	0.9044	More...
Q9Y3R5	Protein dopey-2	DEG_SPOP_SBC_1	1204:1208	ALTTS	SPOP	0.8427	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons