DegronMD

Uniprot ID: Q8N139

Source protein: ATP-binding cassette sub-family A member 6

Source gene: ABCA6

Class: DEG_SPOP_SBC_1

Location: 1265:1269

E3 ligase: SPOP

DEGRON score: 0.6087

ASA_SCORE: 67.36

COIL: 0.6866

CONS_SCORE: 0.253

DSS_SCORE: 0.3662

HELIX: 0.2986

FCONS_SCORE: 0.7179

RIG_SCORE: 0.8134

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1272Y	TCGA-AJ-A5DW	UCEC	TCGA	ALTTS	DEG_SPOP_SBC_1	0.25
p.D1272Y	DO50075	UCEC	ICGC	ALTTS	DEG_SPOP_SBC_1	0.25
p.T1257I	TCGA-AX-A2HD	UCEC	TCGA	ALTTS	DEG_SPOP_SBC_1	0.1111
p.T1257I	DO42608	UCEC	ICGC	ALTTS	DEG_SPOP_SBC_1	0.1111
p.E1273K	TCGA-D8-A27G	BRCA	TCGA	ALTTS	DEG_SPOP_SBC_1	0.2222
p.E1273K	SIDM00454	Rhabdomyosarcoma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.2222
p.R1259K	TCGA-EO-A22X	UCEC	TCGA	ALTTS	DEG_SPOP_SBC_1	0.1667
p.R1259K	DO43907	UCEC	ICGC	ALTTS	DEG_SPOP_SBC_1	0.1667
p.R1261K	DO48413	BLCA	ICGC	ALTTS	DEG_SPOP_SBC_1	0.2222
p.R1261K	DO232031	LICA	ICGC	ALTTS	DEG_SPOP_SBC_1	0.2222
p.A1265D	DO228971	LICA	ICGC	ALTTS	DEG_SPOP_SBC_1	0.7793
p.T1257K	DO229036	LICA	ICGC	ALTTS	DEG_SPOP_SBC_1	0.1111
p.I1260V	SIDM00434	Plasma Cell Myeloma	GDSC	ALTTS	DEG_SPOP_SBC_1	0.1944
p.I1260V	ACH-000745	Myeloma	CCLE	ALTTS	DEG_SPOP_SBC_1	0.1944
p.I1260V	MOLP-8	haematopoietic_and_lymphoid_tissue	COSMIC	ALTTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	3900:3904	ALTTS	SPOP	0.8153	More...
Q5T1M5	FK506-binding protein 15	DEG_SPOP_SBC_1	998:1002	ALTTS	SPOP	0.6317	More...
Q8IZQ8	Myocardin	DEG_SPOP_SBC_1	906:910	ALTTS	SPOP	0.987	More...
Q8N139	ATP-binding cassette sub-family A member 6	DEG_SPOP_SBC_1	1265:1269	ALTTS	SPOP	0.6087	More...
Q8N350	Voltage-dependent calcium channel beta subunit-associated regulatory protein	DEG_SPOP_SBC_1	22:26	ALTTS	SPOP	0.7614	More...
Q9H422	Homeodomain-interacting protein kinase 3	DEG_SPOP_SBC_1	592:596	ALTTS	SPOP	0.9044	More...
Q9Y3R5	Protein dopey-2	DEG_SPOP_SBC_1	1204:1208	ALTTS	SPOP	0.8427	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons