DegronMD - Q8N139(ABCA6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M1606T	TCGA-AA-3845	COAD	TCGA	LLPHSD	LIG_APCC_ABBA_1	1610:1615	Mutation rewiring degron network	0.2222
p.M1606T	DO10020	COAD	ICGC	LLPHSD	LIG_APCC_ABBA_1	1610:1615	Mutation rewiring degron network	0.2222
p.D1272Y	TCGA-AJ-A5DW	UCEC	TCGA	ALTTS	DEG_SPOP_SBC_1	1265:1269	Mutation rewiring degron network	0.25
p.D1272Y	DO50075	UCEC	ICGC	ALTTS	DEG_SPOP_SBC_1	1265:1269	Mutation rewiring degron network	0.25
p.K1609E	TCGA-AP-A0LM	UCEC	TCGA	LLPHSD	LIG_APCC_ABBA_1	1610:1615	Mutation rewiring degron network	0.3056
p.K1609E	DO43306	UCEC	ICGC	LLPHSD	LIG_APCC_ABBA_1	1610:1615	Mutation rewiring degron network	0.3056
p.T1257I	TCGA-AX-A2HD	UCEC	TCGA	ALTTS	DEG_SPOP_SBC_1	1265:1269	Mutation rewiring degron network	0.1111
p.T1257I	DO42608	UCEC	ICGC	ALTTS	DEG_SPOP_SBC_1	1265:1269	Mutation rewiring degron network	0.1111
p.E1601K	TCGA-B5-A0JY	UCEC	TCGA	LLPHSD	LIG_APCC_ABBA_1	1610:1615	Mutation rewiring degron network	0.0833
p.E1601K	DO43041	UCEC	ICGC	LLPHSD	LIG_APCC_ABBA_1	1610:1615	Mutation rewiring degron network	0.0833
p.E1273K	TCGA-D8-A27G	BRCA	TCGA	ALTTS	DEG_SPOP_SBC_1	1265:1269	Mutation rewiring degron network	0.2222
p.E1273K	SIDM00454	Rhabdomyosarcoma	GDSC	ALTTS	DEG_SPOP_SBC_1	1265:1269	Mutation rewiring degron network	0.2222
p.R1259K	TCGA-EO-A22X	UCEC	TCGA	ALTTS	DEG_SPOP_SBC_1	1265:1269	Mutation rewiring degron network	0.1667
p.R1259K	DO43907	UCEC	ICGC	ALTTS	DEG_SPOP_SBC_1	1265:1269	Mutation rewiring degron network	0.1667
p.D1603H	TCGA-NC-A5HN	LUSC	TCGA	LLPHSD	LIG_APCC_ABBA_1	1610:1615	Mutation rewiring degron network	0.1389
p.D1603H	DO52025	LUSC	ICGC	LLPHSD	LIG_APCC_ABBA_1	1610:1615	Mutation rewiring degron network	0.1389
p.R1261K	DO48413	BLCA	ICGC	ALTTS	DEG_SPOP_SBC_1	1265:1269	Mutation rewiring degron network	0.2222
p.R1261K	DO232031	LICA	ICGC	ALTTS	DEG_SPOP_SBC_1	1265:1269	Mutation rewiring degron network	0.2222
p.A1265D	DO228971	LICA	ICGC	ALTTS	DEG_SPOP_SBC_1	1265:1269	Mutation altering degron motif	0.7793
p.T1257K	DO229036	LICA	ICGC	ALTTS	DEG_SPOP_SBC_1	1265:1269	Mutation rewiring degron network	0.1111
p.I1260V	SIDM00434	Plasma Cell Myeloma	GDSC	ALTTS	DEG_SPOP_SBC_1	1265:1269	Mutation rewiring degron network	0.1944
p.I1260V	ACH-000745	Myeloma	CCLE	ALTTS	DEG_SPOP_SBC_1	1265:1269	Mutation rewiring degron network	0.1944
p.I1260V	MOLP-8	haematopoietic and lymphoid tissue	COSMIC	ALTTS	DEG_SPOP_SBC_1	1265:1269	Mutation rewiring degron network	0.1944

Kaplan plot for ABCA6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ABCA6

UniProt ID: Q8N139

Entrez ID: 23460

Protein name: ATP-binding cassette sub-family A member 6 (EC 7.6.2.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ABCA6 in