DegronMD

Uniprot ID: Q8N139

Source protein: ATP-binding cassette sub-family A member 6

Source gene: ABCA6

Class: LIG_APCC_ABBA_1

Location: 1610:1615

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8934

ASA_SCORE: 109.5833

COIL: 0.8397

CONS_SCORE: 0.2377

DSS_SCORE: 0.7178

HELIX: 0.1412

FCONS_SCORE: 1.0994

RIG_SCORE: 0.7323

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M1606T	TCGA-AA-3845	COAD	TCGA	LLPHSD	LIG_APCC_ABBA_1	0.2222
p.M1606T	DO10020	COAD	ICGC	LLPHSD	LIG_APCC_ABBA_1	0.2222
p.K1609E	TCGA-AP-A0LM	UCEC	TCGA	LLPHSD	LIG_APCC_ABBA_1	0.3056
p.K1609E	DO43306	UCEC	ICGC	LLPHSD	LIG_APCC_ABBA_1	0.3056
p.E1601K	TCGA-B5-A0JY	UCEC	TCGA	LLPHSD	LIG_APCC_ABBA_1	0.0833
p.E1601K	DO43041	UCEC	ICGC	LLPHSD	LIG_APCC_ABBA_1	0.0833
p.D1603H	TCGA-NC-A5HN	LUSC	TCGA	LLPHSD	LIG_APCC_ABBA_1	0.1389
p.D1603H	DO52025	LUSC	ICGC	LLPHSD	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N139	ATP-binding cassette sub-family A member 6	LIG_APCC_ABBA_1	1610:1615	LLPHSD	APC,CDC20,FZR1	0.8934	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons