DegronMD

Uniprot ID: Q12955

Source protein: Ankyrin-3

Source gene: ANK3

Class: DEG_SPOP_SBC_1

Location: 1726:1730

E3 ligase: SPOP

DEGRON score: 0.9933

ASA_SCORE: 70.1

COIL: 0.8398

CONS_SCORE: 0.4097

DSS_SCORE: 0.2836

HELIX: 0.1198

FCONS_SCORE: 1.1838

RIG_SCORE: 0.737

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1738N	TCGA-AJ-A3EK	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	0.1111
p.T1738N	DO41584	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	0.1111
p.S1721F	TCGA-D3-A2JF	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	0.1944
p.S1721F	TCGA-EE-A2MS	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	0.1944
p.S1721F	TCGA-YG-AA3N	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	0.1944
p.S1721F	DO222868	MELA	ICGC	PSSST	DEG_SPOP_SBC_1	0.1944
p.S1721F	DO37567	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	0.1944
p.S1721F	DO51298	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	0.1944
p.S1721F	DO38153	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	0.1944
p.S1728F	TCGA-EE-A183	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	0.7982
p.S1728F	DO37715	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	0.7982
p.P1726L	TCGA-EE-A3AE	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	0.7582
p.P1726L	DO37802	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	0.7582
p.D1726H	DO1755	BRCA	ICGC	PSSST	DEG_SPOP_SBC_1	0.7688
p.D1719N	DO2204	BRCA	ICGC	PSSST	DEG_SPOP_SBC_1	0.1389
p.S1720I	DO227549	COCA	ICGC	PSSST	DEG_SPOP_SBC_1	0.1667
p.P1721H	DO37835	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	0.1944
p.E1740K	DO50297	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	0.0556
p.T1729A	DO41644	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	0.7139
p.L1725I	DO41572	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	0.3056
p.D1718Y	DO43971	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	0.1111
p.T1740M	SIDM00525	Osteosarcoma	GDSC	PSSST	DEG_SPOP_SBC_1	0.0556
p.T1740M	SIDM00217	Colorectal Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	0.0556
p.T1740M	ACH-000359	Bone Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	0.0556
p.T1740M	ACH-000999	Colon/Colorectal Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	0.0556
p.T1740M	SNU-1040	large_intestine	COSMIC	PSSST	DEG_SPOP_SBC_1	0.0556
p.T1740M	MG-63	bone	COSMIC	PSSST	DEG_SPOP_SBC_1	0.0556
p.N1733D	SIDM01608	Endometrial Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	0.25
p.N1733D	ACH-000990	Endometrial/Uterine Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NJ46	Homeobox protein Nkx-6.3	DEG_SPOP_SBC_1	202:206	PSSST	SPOP	0.9	More...
O14986	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	DEG_SPOP_SBC_1	505:509	PSSST	SPOP	0.9262	More...
O75509	Tumor necrosis factor receptor superfamily member 21	DEG_SPOP_SBC_1	5:9	PSSST	SPOP	0.5341	More...
Q02446	Transcription factor Sp4	DEG_SPOP_SBC_1	318:322	PSSST	SPOP	0.9616	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2215:2219	PSSST	SPOP	0.6889	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	994:998	PSSST	SPOP	0.9774	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	1726:1730	PSSST	SPOP	0.9933	More...
Q13233	Mitogen-activated protein kinase kinase kinase 1	DEG_SPOP_SBC_1	938:942	PSSST	SPOP	0.9979	More...
Q13233	Mitogen-activated protein kinase kinase kinase 1	DEG_SPOP_SBC_1	986:990	PSSST	SPOP	0.9935	More...
Q13495	Mastermind-like domain-containing protein 1	DEG_SPOP_SBC_1	254:258	PSSST	SPOP	0.9751	More...
Q14209	Transcription factor E2F2	DEG_SPOP_SBC_1	333:337	PSSST	SPOP	0.9654	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	1309:1313	PSSST	SPOP	0.9397	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1204:1208	PSSST	SPOP	0.9958	More...
Q6Y7W6	GRB10-interacting GYF protein 2	DEG_SPOP_SBC_1	924:928	PSSST	SPOP	0.9123	More...
Q70EL1	Inactive ubiquitin carboxyl-terminal hydrolase 54	DEG_SPOP_SBC_1	498:502	PSSST	SPOP	0.5622	More...
Q8IWI9	MAX gene-associated protein	DEG_SPOP_SBC_1	1469:1473	PSSST	SPOP	0.9959	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	1349:1353	PSSST	SPOP	0.9813	More...
Q96NM4	TOX high mobility group box family member 2	DEG_SPOP_SBC_1	212:216	PSSST	SPOP	0.9686	More...
Q9C0D5	Protein TANC1	DEG_SPOP_SBC_1	466:470	PSSST	SPOP	0.9963	More...
Q9H204	Mediator of RNA polymerase II transcription subunit 28	DEG_SPOP_SBC_1	39:43	PSSST	SPOP	0.9773	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2120:2124	PSSST	SPOP	0.9022	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2677:2681	PSSST	SPOP	0.997	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3377:3381	PSSST	SPOP	0.9878	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3934:3938	PSSST	SPOP	0.5887	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4667:4671	PSSST	SPOP	0.896	More...
Q9NRE2	Teashirt homolog 2	DEG_SPOP_SBC_1	721:725	PSSST	SPOP	0.9083	More...
Q9P0K1	Disintegrin and metalloproteinase domain-containing protein 22	DEG_SPOP_SBC_1	867:871	PSSST	SPOP	0.9989	More...
Q9P278	Folliculin-interacting protein 2	DEG_SPOP_SBC_1	256:260	PSSST	SPOP	0.9927	More...
Q9UJY4	ADP-ribosylation factor-binding protein GGA2	DEG_SPOP_SBC_1	399:403	PSSST	SPOP	0.9967	More...
Q9Y463	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	DEG_SPOP_SBC_1	459:463	PSSST	SPOP	0.8712	More...
Q9Y4E5	E3 SUMO-protein ligase ZNF451	DEG_SPOP_SBC_1	572:576	PSSST	SPOP	0.9842	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	704:708	PSSST	SPOP	0.9079	More...
Q96P26	Cytosolic 5'-nucleotidase 1B	DEG_SPOP_SBC_1	148:152	PSSST	SPOP	0.9953	More...
Q96S82	Ubiquitin-like protein 7	DEG_SPOP_SBC_1	244:248	PSSST	SPOP	0.9487	More...
Q6ZU67	BEN domain-containing protein 4	DEG_SPOP_SBC_1	305:309	PSSST	SPOP	0.9981	More...
Q9H5J0	Zinc finger and BTB domain-containing protein 3	DEG_SPOP_SBC_1	272:276	PSSST	SPOP	0.9351	More...
Q9ULL1	Pleckstrin homology domain-containing family G member 1	DEG_SPOP_SBC_1	514:518	PSSST	SPOP	0.7015	More...
Q96H35	Probable RNA-binding protein 18	DEG_SPOP_SBC_1	126:130	PSSST	SPOP	0.9314	More...
Q9BXQ6	Transmembrane protein 121B	DEG_SPOP_SBC_1	68:72	PSSST	SPOP	0.9951	More...
Q9BY89	Uncharacterized protein KIAA1671	DEG_SPOP_SBC_1	139:143	PSSST	SPOP	0.9816	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSST

Degron related mutations and impact score

Drug responses associated with ANK3 mutations

All proteins holding degron of PSSST