DegronMD - Q9Y4E5(ZNF451)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I46T	TCGA-06-0939	GBM	TCGA	LRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.7078
p.I46T	DO12130	GBM	ICGC	LRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.7078
p.R40P	TCGA-4Z-AA84	BLCA	TCGA	LRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.7512
p.R40P	DO218988	BLCA	ICGC	LRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.7512
p.A583S	TCGA-75-5126	LUAD	TCGA	PSSST	DEG_SPOP_SBC_1	572:576	Mutation rewiring degron network	0.1389
p.A583S	DO228929	LICA	ICGC	PSSST	DEG_SPOP_SBC_1	572:576	Mutation rewiring degron network	0.1389
p.A583S	DO23711	LUAD	ICGC	PSSST	DEG_SPOP_SBC_1	572:576	Mutation rewiring degron network	0.1389
p.P572L	TCGA-BH-A0HF	BRCA	TCGA	PSSST	DEG_SPOP_SBC_1	572:576	Mutation altering degron motif	0.7582
p.P572L	DO1749	BRCA	ICGC	PSSST	DEG_SPOP_SBC_1	572:576	Mutation altering degron motif	0.7582
p.S573L	TCGA-D3-A8GQ	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	572:576	Mutation altering degron motif	0.6556
p.S573L	DO51246	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	572:576	Mutation altering degron motif	0.6556
p.D47Y	TCGA-EE-A183	SKCM	TCGA	LRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.6214
p.D47Y	DO37715	SKCM	ICGC	LRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.6214
p.L43I	TCGA-GF-A6C9	SKCM	TCGA	LRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.7174
p.L43I	DO51254	SKCM	ICGC	LRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.7174
p.R40Q	TCGA-VQ-A91D	STAD	TCGA	LRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.7329
p.R40Q	DO51783	STAD	ICGC	LRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.7329
p.R40Q	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	LRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.7329
p.R40Q	ACH-000925	Lung Cancer	CCLE	LRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.7329
p.E562K	DO225282	BRCA	ICGC	PSSST	DEG_SPOP_SBC_1	572:576	Mutation rewiring degron network	0.0556
p.M563I	DO228976	LICA	ICGC	PSSST	DEG_SPOP_SBC_1	572:576	Mutation rewiring degron network	0.0833
p.L43V	DO232072	ORCA	ICGC	LRPVLEYID	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.6765
p.N580I	SIDM01156	Small Cell Lung Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	572:576	Mutation rewiring degron network	0.2222
p.N580I	ACH-000890	Lung Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	572:576	Mutation rewiring degron network	0.2222
p.T582S	SIDM01156	Small Cell Lung Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	572:576	Mutation rewiring degron network	0.1667
p.T582S	ACH-000890	Lung Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	572:576	Mutation rewiring degron network	0.1667

Kaplan plot for ZNF451 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF451

UniProt ID: Q9Y4E5

Entrez ID: 26036

Protein name: E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF451 in