DegronMD

Uniprot ID: Q9Y4E5

Source protein: E3 SUMO-protein ligase ZNF451

Source gene: ZNF451

Class: DEG_APCC_DBOX_1

Location: 39:47

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9029

ASA_SCORE: 52.0778

COIL: 0.3501

CONS_SCORE: 0.7189

DSS_SCORE: 0.5049

HELIX: 0.3939

FCONS_SCORE: 1.0389

RIG_SCORE: 0.8015

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I46T	TCGA-06-0939	GBM	TCGA	LRPVLEYID	DEG_APCC_DBOX_1	0.7078
p.I46T	DO12130	GBM	ICGC	LRPVLEYID	DEG_APCC_DBOX_1	0.7078
p.R40P	TCGA-4Z-AA84	BLCA	TCGA	LRPVLEYID	DEG_APCC_DBOX_1	0.7512
p.R40P	DO218988	BLCA	ICGC	LRPVLEYID	DEG_APCC_DBOX_1	0.7512
p.D47Y	TCGA-EE-A183	SKCM	TCGA	LRPVLEYID	DEG_APCC_DBOX_1	0.6214
p.D47Y	DO37715	SKCM	ICGC	LRPVLEYID	DEG_APCC_DBOX_1	0.6214
p.L43I	TCGA-GF-A6C9	SKCM	TCGA	LRPVLEYID	DEG_APCC_DBOX_1	0.7174
p.L43I	DO51254	SKCM	ICGC	LRPVLEYID	DEG_APCC_DBOX_1	0.7174
p.R40Q	TCGA-VQ-A91D	STAD	TCGA	LRPVLEYID	DEG_APCC_DBOX_1	0.7329
p.R40Q	DO51783	STAD	ICGC	LRPVLEYID	DEG_APCC_DBOX_1	0.7329
p.R40Q	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	LRPVLEYID	DEG_APCC_DBOX_1	0.7329
p.R40Q	ACH-000925	Lung Cancer	CCLE	LRPVLEYID	DEG_APCC_DBOX_1	0.7329
p.L43V	DO232072	ORCA	ICGC	LRPVLEYID	DEG_APCC_DBOX_1	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4E5	E3 SUMO-protein ligase ZNF451	DEG_APCC_DBOX_1	39:47	LRPVLEYID	APC,CDC20,FZR1	0.9029	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons