DegronMD

Uniprot ID: Q9Y463

Source protein: Dual specificity tyrosine-phosphorylation-regulated kinase 1B

Source gene: DYRK1B

Class: DEG_SPOP_SBC_1

Location: 459:463

E3 ligase: SPOP

DEGRON score: 0.8712

ASA_SCORE: 91.18

COIL: 0.9554

CONS_SCORE: 0.3012

DSS_SCORE: 0.5804

HELIX: 0.0326

FCONS_SCORE: 1.031

RIG_SCORE: 0.5929

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I467F	TCGA-55-8510	LUAD	TCGA	PSSST	DEG_SPOP_SBC_1	0.2222
p.P452H	TCGA-EO-A22T	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	0.1389
p.C458Y	TCGA-QK-A8Z7	HNSC	TCGA	PSSST	DEG_SPOP_SBC_1	0.3056
p.G464D	DO233272	GACA	ICGC	PSSST	DEG_SPOP_SBC_1	0.3056
p.I469V	DO49659	LIHC	ICGC	PSSST	DEG_SPOP_SBC_1	0.1667
p.P468T	DO23774	LUAD	ICGC	PSSST	DEG_SPOP_SBC_1	0.1944
p.R456C	DO228322	MALY	ICGC	PSSST	DEG_SPOP_SBC_1	0.25
p.R456C	Ramos-2G6-4C10	haematopoietic_and_lymphoid_tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	0.25
p.P465S	DO220851	MELA	ICGC	PSSST	DEG_SPOP_SBC_1	0.2778
p.S458R	DO219317	PRAD	ICGC	PSSST	DEG_SPOP_SBC_1	0.3056
p.S458I	DO52402	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	0.3056
p.S462R	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	PSSST	DEG_SPOP_SBC_1	0.7427
p.A464T	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSSST	DEG_SPOP_SBC_1	0.3056
p.A464T	ACH-001498	Lymphoma	CCLE	PSSST	DEG_SPOP_SBC_1	0.3056
p.A464T	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	0.3056
p.R456H	SNU-175	large_intestine	COSMIC	PSSST	DEG_SPOP_SBC_1	0.25
p.C462Y	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	0.7087
p.C450Y	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	0.0833

Drug responses associated with DYRK1B mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00918	OV\|ovary	p.A71G (No)	GDSC	Dyrk1b_0191	14.1306
SIDM01177	UNCLASSIFIED\|B_cell_leukemia	p.A71G (No)	GDSC	Dyrk1b_0191	81.3101
SIDM00941	KIRC\|kidney	p.A71G (No)	GDSC	Dyrk1b_0191	5.3501
SIDM00813	UNCLASSIFIED\|Hodgkin_lymphoma	p.A71G (No)	GDSC	Dyrk1b_0191	33.5779
SIDM00688	DLBC\|B_cell_lymphoma	p.A36P (No)	GDSC	Dyrk1b_0191	59.042
SIDM01086	ALL\|leukemia	p.R280H (No)	GDSC	Dyrk1b_0191	9.0663
SIDM00945	COREAD\|large_intestine	p.Q545fs*30 (No)	GDSC	Dyrk1b_0191	10.866
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.A71G (No)	GDSC	Dyrk1b_0191	3.6176
SIDM00499	PRAD\|prostate	p.A71G (No)	GDSC	Dyrk1b_0191	8.6457
SIDM00145	ALL\|lymphoblastic_leukemia	p.A71G (No)	GDSC	Dyrk1b_0191	5.2066
SIDM01032	ESCA\|oesophagus	p.Q272H (No)	GDSC	Dyrk1b_0191	3.4783
SIDM00380	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.A71G (No)	GDSC	Dyrk1b_0191	7.2613
SIDM00121	ALL\|lymphoblastic_leukemia	p.C490Y (No)	GDSC	Dyrk1b_0191	11.7659
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.A71G (No)	GDSC	Dyrk1b_0191	11.844
SIDM00782	COREAD\|large_intestine	p.P552L (No)	GDSC	Dyrk1b_0191	8.0632
SIDM00683	PRAD\|prostate	p.T308A (No)	GDSC	Dyrk1b_0191	5.4242
SIDM00997	THCA\|thyroid	p.A71G (No)	GDSC	Dyrk1b_0191	4.1277
SIDM00460	DLBC\|B_cell_lymphoma	p.A71G (No)	GDSC	Dyrk1b_0191	7.9106
SIDM00901	UCEC\|endometrium	p.A71G (No)	GDSC	Dyrk1b_0191	16.3679
SIDM00901	UCEC\|endometrium	p.V62G (No)	GDSC	Dyrk1b_0191	16.3679
SIDM00964	UNCLASSIFIED\|prostate	p.A71G (No)	GDSC	Dyrk1b_0191	3.4134
SIDM00859	DLBC\|B_cell_lymphoma	p.A464T (Yes)	GDSC	Dyrk1b_0191	69.0862
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.K345N (No)	GDSC	Dyrk1b_0191	7.6316
SIDM00453	PAAD\|pancreas	p.A71G (No)	GDSC	Dyrk1b_0191	16.3154
SIDM01048	MM\|lymphoid_neoplasm_other	p.A71G (No)	GDSC	Dyrk1b_0191	60.8024
SIDM00235	KIRC\|kidney	p.A71G (No)	GDSC	Dyrk1b_0191	1.8083
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.A71G (No)	GDSC	Dyrk1b_0191	92.2004
SIDM00762	LUAD\|lung_NSCLC_adenocarcinoma	p.A71G (No)	GDSC	Dyrk1b_0191	2.7902
SIDM01229	NB\|neuroblastoma	p.A71G (No)	GDSC	Dyrk1b_0191	18.8068
SIDM00202	UNCLASSIFIED\|ewings_sarcoma	p.G352A (No)	GDSC	Dyrk1b_0191	4.3788
SIDM00214	COREAD\|large_intestine	p.A71G (No)	GDSC	Dyrk1b_0191	8.389
SIDM01088	UNCLASSIFIED\|endometrium	p.R202C (No)	GDSC	Dyrk1b_0191	3.5233
SIDM01088	UNCLASSIFIED\|endometrium	p.A71G (No)	GDSC	Dyrk1b_0191	3.5233
SIDM00003	SKCM\|melanoma	p.I257N (No)	GDSC	Dyrk1b_0191	2.31
SIDM00633	BRCA\|breast	p.A71G (No)	GDSC	Dyrk1b_0191	5.7224
SIDM01043	UNCLASSIFIED\|endometrium	p.A71G (No)	GDSC	Dyrk1b_0191	8.5464
SIDM00484	THCA\|thyroid	p.A71G (No)	GDSC	Dyrk1b_0191	4.9991
SIDM00431	ALL\|lymphoblastic_T_cell_leukaemia	p.A71G (No)	GDSC	Dyrk1b_0191	5.0084
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.V62G (No)	GDSC	Dyrk1b_0191	9.4483
SIDM00504	LGG\|glioma	p.A71G (No)	GDSC	Dyrk1b_0191	7.7151
SIDM01089	DLBC\|B_cell_lymphoma	p.A71G (No)	GDSC	Dyrk1b_0191	4.7678
SIDM00577	NB\|neuroblastoma	p.A71G (No)	GDSC	Dyrk1b_0191	5.0284
SIDM01019	LAML\|acute_myeloid_leukaemia	p.K361E (No)	GDSC	Dyrk1b_0191	25.9588
SIDM01019	LAML\|acute_myeloid_leukaemia	p.A71G (No)	GDSC	Dyrk1b_0191	25.9588
SIDM00404	DLBC\|B_cell_lymphoma	p.A71G (No)	GDSC	Dyrk1b_0191	6.4915
SIDM00042	PAAD\|pancreas	p.A71G (No)	GDSC	Dyrk1b_0191	2.7004
SIDM00489	HNSC\|head_and_neck	p.A71G (No)	GDSC	Dyrk1b_0191	19.8104
SIDM00217	COREAD\|large_intestine	p.R324H (No)	GDSC	Dyrk1b_0191	29.0772
SIDM00217	COREAD\|large_intestine	p.R110H (No)	GDSC	Dyrk1b_0191	29.0772
SIDM00217	COREAD\|large_intestine	p.R102H (No)	GDSC	Dyrk1b_0191	29.0772
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.A71G (No)	GDSC	Dyrk1b_0191	5.5161
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A71G (No)	GDSC	Dyrk1b_0191	34.9538
SIDM00395	NB\|neuroblastoma	p.G352A (No)	GDSC	Dyrk1b_0191	14.9618
SIDM01247	UNCLASSIFIED\|Burkitt_lymphoma	p.R484C (No)	GDSC	Dyrk1b_0191	13.8127
SIDM01114	PRAD\|prostate	p.A254T (No)	GDSC	Dyrk1b_0191	2.5505
SIDM00231	KIRC\|kidney	p.R349W (No)	GDSC	Dyrk1b_0191	8.195
SIDM01006	MM\|haematopoietic_neoplasm_other	p.A71G (No)	GDSC	Dyrk1b_0191	19.1521
SIDM00406	DLBC\|B_cell_lymphoma	p.A71G (No)	GDSC	Dyrk1b_0191	5.3287
SIDM00637	DLBC\|B_cell_lymphoma	p.R551H (No)	GDSC	Dyrk1b_0191	12.1416
SIDM00660	COREAD\|large_intestine	p.T230A (No)	GDSC	Dyrk1b_0191	4.2454
SIDM00955	SKCM\|melanoma	p.A71G (No)	GDSC	Dyrk1b_0191	12.6408
SIDM00969	OV\|ovary	p.R344C (No)	GDSC	Dyrk1b_0191	5.7888
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A71G (No)	GDSC	Dyrk1b_0191	6.4302
SIDM00125	KIRC\|kidney	p.A71G (No)	GDSC	Dyrk1b_0191	5.219
SIDM00257	NB\|neuroblastoma	p.A71G (No)	GDSC	Dyrk1b_0191	4.6734
SIDM00413	DLBC\|B_cell_lymphoma	p.A71G (No)	GDSC	Dyrk1b_0191	0.0096
SIDM00371	PAAD\|pancreas	p.A71G (No)	GDSC	Dyrk1b_0191	4.0308
SIDM00555	GBM\|glioma	p.K145R (No)	GDSC	Dyrk1b_0191	62.0707
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.H237Y (No)	GDSC	Dyrk1b_0191	11.8733
SIDM00040	STAD\|stomach	p.G118D (No)	GDSC	Dyrk1b_0191	7.1446
SIDM00185	SKCM\|melanoma	p.Q275R (No)	GDSC	Dyrk1b_0191	3.9712
SIDM00528	BRCA\|breast	p.A71G (No)	GDSC	Dyrk1b_0191	5.0562
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.A71G (No)	GDSC	Dyrk1b_0191	32.58
SIDM00986	HNSC\|head_and_neck	p.A71G (No)	GDSC	Dyrk1b_0191	5.8016
SIDM00218	THCA\|thyroid	p.A71G (No)	GDSC	Dyrk1b_0191	8.6277
SIDM00346	LCML\|chronic_myeloid_leukaemia	p.A71G (No)	GDSC	Dyrk1b_0191	113.5307
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.C264R (No)	GDSC	Dyrk1b_0191	17.2241
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.A71G (No)	GDSC	Dyrk1b_0191	77.1968
SIDM00594	LAML\|acute_myeloid_leukaemia	p.A71G (No)	GDSC	Dyrk1b_0191	5.0019
SIDM00299	UNCLASSIFIED\|soft_tissue_other	p.A71G (No)	GDSC	Dyrk1b_0191	8.775
SIDM00105	OV\|ovary	p.R593W (No)	GDSC	Dyrk1b_0191	5.2287
SIDM01001	BRCA\|breast	p.R70Q (No)	GDSC	Dyrk1b_0191	11.2687
SIDM00238	OV\|ovary	p.T308N (No)	GDSC	Dyrk1b_0191	10.3301
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.A71G (No)	GDSC	Dyrk1b_0191	26.7732
SIDM00424	UNCLASSIFIED\|B_cell_leukemia	p.A71G (No)	GDSC	Dyrk1b_0191	14.2663
SIDM00356	LUAD\|lung_NSCLC_adenocarcinoma	p.A71G (No)	GDSC	Dyrk1b_0191	7.8238

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NJ46	Homeobox protein Nkx-6.3	DEG_SPOP_SBC_1	202:206	PSSST	SPOP	0.9	More...
O14986	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	DEG_SPOP_SBC_1	505:509	PSSST	SPOP	0.9262	More...
O75509	Tumor necrosis factor receptor superfamily member 21	DEG_SPOP_SBC_1	5:9	PSSST	SPOP	0.5341	More...
Q02446	Transcription factor Sp4	DEG_SPOP_SBC_1	318:322	PSSST	SPOP	0.9616	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2215:2219	PSSST	SPOP	0.6889	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	994:998	PSSST	SPOP	0.9774	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	1726:1730	PSSST	SPOP	0.9933	More...
Q13233	Mitogen-activated protein kinase kinase kinase 1	DEG_SPOP_SBC_1	938:942	PSSST	SPOP	0.9979	More...
Q13233	Mitogen-activated protein kinase kinase kinase 1	DEG_SPOP_SBC_1	986:990	PSSST	SPOP	0.9935	More...
Q13495	Mastermind-like domain-containing protein 1	DEG_SPOP_SBC_1	254:258	PSSST	SPOP	0.9751	More...
Q14209	Transcription factor E2F2	DEG_SPOP_SBC_1	333:337	PSSST	SPOP	0.9654	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	1309:1313	PSSST	SPOP	0.9397	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1204:1208	PSSST	SPOP	0.9958	More...
Q6Y7W6	GRB10-interacting GYF protein 2	DEG_SPOP_SBC_1	924:928	PSSST	SPOP	0.9123	More...
Q70EL1	Inactive ubiquitin carboxyl-terminal hydrolase 54	DEG_SPOP_SBC_1	498:502	PSSST	SPOP	0.5622	More...
Q8IWI9	MAX gene-associated protein	DEG_SPOP_SBC_1	1469:1473	PSSST	SPOP	0.9959	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	1349:1353	PSSST	SPOP	0.9813	More...
Q96NM4	TOX high mobility group box family member 2	DEG_SPOP_SBC_1	212:216	PSSST	SPOP	0.9686	More...
Q9C0D5	Protein TANC1	DEG_SPOP_SBC_1	466:470	PSSST	SPOP	0.9963	More...
Q9H204	Mediator of RNA polymerase II transcription subunit 28	DEG_SPOP_SBC_1	39:43	PSSST	SPOP	0.9773	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2120:2124	PSSST	SPOP	0.9022	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2677:2681	PSSST	SPOP	0.997	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3377:3381	PSSST	SPOP	0.9878	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3934:3938	PSSST	SPOP	0.5887	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4667:4671	PSSST	SPOP	0.896	More...
Q9NRE2	Teashirt homolog 2	DEG_SPOP_SBC_1	721:725	PSSST	SPOP	0.9083	More...
Q9P0K1	Disintegrin and metalloproteinase domain-containing protein 22	DEG_SPOP_SBC_1	867:871	PSSST	SPOP	0.9989	More...
Q9P278	Folliculin-interacting protein 2	DEG_SPOP_SBC_1	256:260	PSSST	SPOP	0.9927	More...
Q9UJY4	ADP-ribosylation factor-binding protein GGA2	DEG_SPOP_SBC_1	399:403	PSSST	SPOP	0.9967	More...
Q9Y463	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	DEG_SPOP_SBC_1	459:463	PSSST	SPOP	0.8712	More...
Q9Y4E5	E3 SUMO-protein ligase ZNF451	DEG_SPOP_SBC_1	572:576	PSSST	SPOP	0.9842	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	704:708	PSSST	SPOP	0.9079	More...
Q96P26	Cytosolic 5'-nucleotidase 1B	DEG_SPOP_SBC_1	148:152	PSSST	SPOP	0.9953	More...
Q96S82	Ubiquitin-like protein 7	DEG_SPOP_SBC_1	244:248	PSSST	SPOP	0.9487	More...
Q6ZU67	BEN domain-containing protein 4	DEG_SPOP_SBC_1	305:309	PSSST	SPOP	0.9981	More...
Q9H5J0	Zinc finger and BTB domain-containing protein 3	DEG_SPOP_SBC_1	272:276	PSSST	SPOP	0.9351	More...
Q9ULL1	Pleckstrin homology domain-containing family G member 1	DEG_SPOP_SBC_1	514:518	PSSST	SPOP	0.7015	More...
Q96H35	Probable RNA-binding protein 18	DEG_SPOP_SBC_1	126:130	PSSST	SPOP	0.9314	More...
Q9BXQ6	Transmembrane protein 121B	DEG_SPOP_SBC_1	68:72	PSSST	SPOP	0.9951	More...
Q9BY89	Uncharacterized protein KIAA1671	DEG_SPOP_SBC_1	139:143	PSSST	SPOP	0.9816	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSST

Degron related mutations and impact score

Drug responses associated with DYRK1B mutations

All proteins holding degron of PSSST