DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PSSST
Uniprot ID:
Q9UJY4
Source protein:
ADP-ribosylation factor-binding protein GGA2
Source gene:
GGA2
Class:
DEG_SPOP_SBC_1
Location:
399:403
E3 ligase:
SPOP
DEGRON score:
0.9967
ASA_SCORE:
71.84
COIL:
0.94
CONS_SCORE:
0.3719
DSS_SCORE:
0.6124
HELIX:
0.0472
FCONS_SCORE:
1.084
RIG_SCORE:
0.6044
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P405L
TCGA-DD-A1EE
LIHC
TCGA
PSSST
DEG_SPOP_SBC_1
0.2778
p.P405L
DO22857
LIHC
ICGC
PSSST
DEG_SPOP_SBC_1
0.2778
p.G408D
TCGA-EE-A20C
SKCM
TCGA
PSSST
DEG_SPOP_SBC_1
0.1944
p.G408D
DO47665
SKCM
ICGC
PSSST
DEG_SPOP_SBC_1
0.1944
p.G408S
TCGA-EE-A20C
SKCM
TCGA
PSSST
DEG_SPOP_SBC_1
0.1944
p.G408S
DO47665
SKCM
ICGC
PSSST
DEG_SPOP_SBC_1
0.1944
p.T403M
TCGA-EE-A2MQ
SKCM
TCGA
PSSST
DEG_SPOP_SBC_1
0.8534
p.T403M
DO37810
SKCM
ICGC
PSSST
DEG_SPOP_SBC_1
0.8534
p.G407S
DO228974
LICA
ICGC
PSSST
DEG_SPOP_SBC_1
0.2222
p.G408N
DO222775
MELA
ICGC
PSSST
DEG_SPOP_SBC_1
0.1944
p.S400F
DO229462
SKCA
ICGC
PSSST
DEG_SPOP_SBC_1
0.7982
p.S413C
SIDM01085
Bladder Carcinoma
GDSC
PSSST
DEG_SPOP_SBC_1
0.0556
p.S413C
ACH-000242
Bladder Cancer
CCLE
PSSST
DEG_SPOP_SBC_1
0.0556
p.S413C
RT4
urinary_tract
COSMIC
PSSST
DEG_SPOP_SBC_1
0.0556
Drug responses associated with GGA2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PSSST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NJ46
Homeobox protein Nkx-6.3
DEG_SPOP_SBC_1
202:206
PSSST
SPOP
0.9
More...
O14986
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
DEG_SPOP_SBC_1
505:509
PSSST
SPOP
0.9262
More...
O75509
Tumor necrosis factor receptor superfamily member 21
DEG_SPOP_SBC_1
5:9
PSSST
SPOP
0.5341
More...
Q02446
Transcription factor Sp4
DEG_SPOP_SBC_1
318:322
PSSST
SPOP
0.9616
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
2215:2219
PSSST
SPOP
0.6889
More...
Q03164
Histone-lysine N-methyltransferase 2A
DEG_SPOP_SBC_1
994:998
PSSST
SPOP
0.9774
More...
Q12955
Ankyrin-3
DEG_SPOP_SBC_1
1726:1730
PSSST
SPOP
0.9933
More...
Q13233
Mitogen-activated protein kinase kinase kinase 1
DEG_SPOP_SBC_1
938:942
PSSST
SPOP
0.9979
More...
Q13233
Mitogen-activated protein kinase kinase kinase 1
DEG_SPOP_SBC_1
986:990
PSSST
SPOP
0.9935
More...
Q13495
Mastermind-like domain-containing protein 1
DEG_SPOP_SBC_1
254:258
PSSST
SPOP
0.9751
More...
Q14209
Transcription factor E2F2
DEG_SPOP_SBC_1
333:337
PSSST
SPOP
0.9654
More...
Q15652
Probable JmjC domain-containing histone demethylation protein 2C
DEG_SPOP_SBC_1
1309:1313
PSSST
SPOP
0.9397
More...
Q4ZHG4
Fibronectin type III domain-containing protein 1
DEG_SPOP_SBC_1
1204:1208
PSSST
SPOP
0.9958
More...
Q6Y7W6
GRB10-interacting GYF protein 2
DEG_SPOP_SBC_1
924:928
PSSST
SPOP
0.9123
More...
Q70EL1
Inactive ubiquitin carboxyl-terminal hydrolase 54
DEG_SPOP_SBC_1
498:502
PSSST
SPOP
0.5622
More...
Q8IWI9
MAX gene-associated protein
DEG_SPOP_SBC_1
1469:1473
PSSST
SPOP
0.9959
More...
Q8N3K9
Cardiomyopathy-associated protein 5
DEG_SPOP_SBC_1
1349:1353
PSSST
SPOP
0.9813
More...
Q96NM4
TOX high mobility group box family member 2
DEG_SPOP_SBC_1
212:216
PSSST
SPOP
0.9686
More...
Q9C0D5
Protein TANC1
DEG_SPOP_SBC_1
466:470
PSSST
SPOP
0.9963
More...
Q9H204
Mediator of RNA polymerase II transcription subunit 28
DEG_SPOP_SBC_1
39:43
PSSST
SPOP
0.9773
More...
Q9HC84
Mucin-5B
DEG_SPOP_SBC_1
2120:2124
PSSST
SPOP
0.9022
More...
Q9HC84
Mucin-5B
DEG_SPOP_SBC_1
2677:2681
PSSST
SPOP
0.997
More...
Q9HC84
Mucin-5B
DEG_SPOP_SBC_1
3377:3381
PSSST
SPOP
0.9878
More...
Q9HC84
Mucin-5B
DEG_SPOP_SBC_1
3934:3938
PSSST
SPOP
0.5887
More...
Q9HC84
Mucin-5B
DEG_SPOP_SBC_1
4667:4671
PSSST
SPOP
0.896
More...
Q9NRE2
Teashirt homolog 2
DEG_SPOP_SBC_1
721:725
PSSST
SPOP
0.9083
More...
Q9P0K1
Disintegrin and metalloproteinase domain-containing protein 22
DEG_SPOP_SBC_1
867:871
PSSST
SPOP
0.9989
More...
Q9P278
Folliculin-interacting protein 2
DEG_SPOP_SBC_1
256:260
PSSST
SPOP
0.9927
More...
Q9UJY4
ADP-ribosylation factor-binding protein GGA2
DEG_SPOP_SBC_1
399:403
PSSST
SPOP
0.9967
More...
Q9Y463
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
DEG_SPOP_SBC_1
459:463
PSSST
SPOP
0.8712
More...
Q9Y4E5
E3 SUMO-protein ligase ZNF451
DEG_SPOP_SBC_1
572:576
PSSST
SPOP
0.9842
More...
Q9Y520
Protein PRRC2C
DEG_SPOP_SBC_1
704:708
PSSST
SPOP
0.9079
More...
Q96P26
Cytosolic 5'-nucleotidase 1B
DEG_SPOP_SBC_1
148:152
PSSST
SPOP
0.9953
More...
Q96S82
Ubiquitin-like protein 7
DEG_SPOP_SBC_1
244:248
PSSST
SPOP
0.9487
More...
Q6ZU67
BEN domain-containing protein 4
DEG_SPOP_SBC_1
305:309
PSSST
SPOP
0.9981
More...
Q9H5J0
Zinc finger and BTB domain-containing protein 3
DEG_SPOP_SBC_1
272:276
PSSST
SPOP
0.9351
More...
Q9ULL1
Pleckstrin homology domain-containing family G member 1
DEG_SPOP_SBC_1
514:518
PSSST
SPOP
0.7015
More...
Q96H35
Probable RNA-binding protein 18
DEG_SPOP_SBC_1
126:130
PSSST
SPOP
0.9314
More...
Q9BXQ6
Transmembrane protein 121B
DEG_SPOP_SBC_1
68:72
PSSST
SPOP
0.9951
More...
Q9BY89
Uncharacterized protein KIAA1671
DEG_SPOP_SBC_1
139:143
PSSST
SPOP
0.9816
More...