DegronMD

Uniprot ID: Q15652

Source protein: Probable JmjC domain-containing histone demethylation protein 2C

Source gene: JMJD1C

Class: DEG_SPOP_SBC_1

Location: 1309:1313

E3 ligase: SPOP

DEGRON score: 0.9397

ASA_SCORE: 73.02

COIL: 0.9008

CONS_SCORE: 0.3097

DSS_SCORE: 0.5539

HELIX: 0.0438

FCONS_SCORE: 0.9708

RIG_SCORE: 0.6453

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1311E	DO229006	LICA	ICGC	PSSST	DEG_SPOP_SBC_1	0.7701
p.R1308H	TCGA-2W-A8YY	CESC	TCGA	PSSST	DEG_SPOP_SBC_1	0.3056
p.R1308H	TCGA-B5-A3FA	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	0.3056
p.R1308C	TCGA-A5-A0G2	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	0.3056
p.R1308C	TCGA-AJ-A3OK	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	0.3056
p.R1308C	TCGA-CG-5732	STAD	TCGA	PSSST	DEG_SPOP_SBC_1	0.3056
p.T1307K	DO228971	LICA	ICGC	PSSST	DEG_SPOP_SBC_1	0.2778
p.S1315R	SNU-475	liver	COSMIC	PSSST	DEG_SPOP_SBC_1	0.2778
p.S1317I	TCGA-86-8358	LUAD	TCGA	PSSST	DEG_SPOP_SBC_1	0.2222
p.M1302I	TCGA-50-6593	LUAD	TCGA	PSSST	DEG_SPOP_SBC_1	0.1389
p.M1302I	TCGA-57-1992	OV	TCGA	PSSST	DEG_SPOP_SBC_1	0.1389
p.S1301N	DO38288	STAD	ICGC	PSSST	DEG_SPOP_SBC_1	0.1111
p.T1322K	DO48211	ESCA	ICGC	PSSST	DEG_SPOP_SBC_1	0.0833
p.S1323N	DO233093	GACA	ICGC	PSSST	DEG_SPOP_SBC_1	0.0556

Showing 1 to 14 of 14 entries

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Drug responses associated with JMJD1C mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PSSST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UJY4	ADP-ribosylation factor-binding protein GGA2	DEG_SPOP_SBC_1	399:403	PSSST	SPOP	0.9967	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	1726:1730	PSSST	SPOP	0.9933	More...
Q6ZU67	BEN domain-containing protein 4	DEG_SPOP_SBC_1	305:309	PSSST	SPOP	0.9981	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	1349:1353	PSSST	SPOP	0.9813	More...
Q96P26	Cytosolic 5'-nucleotidase 1B	DEG_SPOP_SBC_1	148:152	PSSST	SPOP	0.9953	More...
Q9P0K1	Disintegrin and metalloproteinase domain-containing protein 22	DEG_SPOP_SBC_1	867:871	PSSST	SPOP	0.9989	More...
Q9Y463	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	DEG_SPOP_SBC_1	459:463	PSSST	SPOP	0.8712	More...
Q9Y4E5	E3 SUMO-protein ligase ZNF451	DEG_SPOP_SBC_1	572:576	PSSST	SPOP	0.9842	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1204:1208	PSSST	SPOP	0.9958	More...
Q9P278	Folliculin-interacting protein 2	DEG_SPOP_SBC_1	256:260	PSSST	SPOP	0.9927	More...
Q6Y7W6	GRB10-interacting GYF protein 2	DEG_SPOP_SBC_1	924:928	PSSST	SPOP	0.9123	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	994:998	PSSST	SPOP	0.9774	More...
A6NJ46	Homeobox protein Nkx-6.3	DEG_SPOP_SBC_1	202:206	PSSST	SPOP	0.9	More...
Q70EL1	Inactive ubiquitin carboxyl-terminal hydrolase 54	DEG_SPOP_SBC_1	498:502	PSSST	SPOP	0.5622	More...
Q13495	Mastermind-like domain-containing protein 1	DEG_SPOP_SBC_1	254:258	PSSST	SPOP	0.9751	More...
Q8IWI9	MAX gene-associated protein	DEG_SPOP_SBC_1	1469:1473	PSSST	SPOP	0.9959	More...
Q9H204	Mediator of RNA polymerase II transcription subunit 28	DEG_SPOP_SBC_1	39:43	PSSST	SPOP	0.9773	More...
Q13233	Mitogen-activated protein kinase kinase kinase 1	DEG_SPOP_SBC_1	938:942	PSSST	SPOP	0.9979	More...
Q13233	Mitogen-activated protein kinase kinase kinase 1	DEG_SPOP_SBC_1	986:990	PSSST	SPOP	0.9935	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	2215:2219	PSSST	SPOP	0.6889	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2120:2124	PSSST	SPOP	0.9022	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2677:2681	PSSST	SPOP	0.997	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3377:3381	PSSST	SPOP	0.9878	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3934:3938	PSSST	SPOP	0.5887	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4667:4671	PSSST	SPOP	0.896	More...

Showing 1 to 25 of 40 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSST

Degron related mutations and impact score

Drug responses associated with JMJD1C mutations

All proteins holding degron of PSSST