DegronMD - Q9UJY4(GGA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R281W	TCGA-19-5956	GBM	TCGA	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7523
p.R281W	DO233693	GACA	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7523
p.R281W	DO13863	GBM	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7523
p.R281W	SIDM00006	Other Solid Cancers	GDSC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7523
p.R281W	ACH-001552	Skin Cancer	CCLE	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7523
p.R281W	MCC26	skin	COSMIC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7523
p.T278M	TCGA-AA-3877	COAD	TCGA	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7423
p.T278M	DO7855	COAD	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7423
p.V268M	TCGA-B5-A3FC	UCEC	TCGA	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.1389
p.V268M	DO41871	UCEC	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.1389
p.P277H	TCGA-BR-4201	STAD	TCGA	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.6583
p.P277H	DO38707	STAD	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.6583
p.E270D	TCGA-CV-7243	HNSC	TCGA	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.1944
p.E270D	DO15382	HNSC	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.1944
p.P405L	TCGA-DD-A1EE	LIHC	TCGA	PSSST	DEG_SPOP_SBC_1	399:403	Mutation rewiring degron network	0.2778
p.P405L	DO22857	LIHC	ICGC	PSSST	DEG_SPOP_SBC_1	399:403	Mutation rewiring degron network	0.2778
p.G408D	TCGA-EE-A20C	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	399:403	Mutation rewiring degron network	0.1944
p.G408D	DO47665	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	399:403	Mutation rewiring degron network	0.1944
p.G408S	TCGA-EE-A20C	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	399:403	Mutation rewiring degron network	0.1944
p.G408S	DO47665	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	399:403	Mutation rewiring degron network	0.1944
p.T403M	TCGA-EE-A2MQ	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	399:403	Mutation altering degron motif	0.8534
p.T403M	DO37810	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	399:403	Mutation altering degron motif	0.8534
p.C272Y	DO234269	ESAD	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.25
p.G407S	DO228974	LICA	ICGC	PSSST	DEG_SPOP_SBC_1	399:403	Mutation rewiring degron network	0.2222
p.A283E	DO229037	LICA	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.659
p.T287A	DO231043	LUSC	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.2222
p.G408N	DO222775	MELA	ICGC	PSSST	DEG_SPOP_SBC_1	399:403	Mutation rewiring degron network	0.1944
p.S400F	DO229462	SKCA	ICGC	PSSST	DEG_SPOP_SBC_1	399:403	Mutation altering degron motif	0.7982
p.D290N	DO229268	THCA	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.1389
p.R276W	SIDM01020	Plasma Cell Myeloma	GDSC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.8634
p.R276W	ACH-000380	Myeloma	CCLE	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.8634
p.R276W	KMS-12-BM	haematopoietic and lymphoid tissue	COSMIC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.8634
p.D288N	SIDM01047	Chronic Myelogenous Leukemia	GDSC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation rewiring degron network	0.1944
p.A283V	SIDM00699	Small Cell Lung Carcinoma	GDSC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.5825
p.A283V	ACH-001138	Lung Cancer	CCLE	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.5825
p.A283V	NCI-H2141	lung	COSMIC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.5825
p.S413C	SIDM01085	Bladder Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	399:403	Mutation rewiring degron network	0.0556
p.S413C	ACH-000242	Bladder Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	399:403	Mutation rewiring degron network	0.0556
p.S413C	RT4	urinary tract	COSMIC	PSSST	DEG_SPOP_SBC_1	399:403	Mutation rewiring degron network	0.0556
p.F280L	SIDM00415	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.587
p.F280L	ACH-001639	Leukemia	CCLE	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.587
p.F280L	ROS-50	haematopoietic and lymphoid tissue	COSMIC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.587

Kaplan plot for GGA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GGA2

UniProt ID: Q9UJY4

Entrez ID: 23062

Protein name: ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GGA2 in