DegronMD - Q9UJY4(GGA2)

FUNCTION: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:1... View more >>

GO - Biological processes (BP): Golgi to plasma membrane protein transport [GO:0043001]; intracellular protein transport [GO:0006886]; protein localization to cell surface [GO:0034394]

GO - Molecular function (MF): phosphatidylinositol binding [GO:0035091]; small GTPase binding [GO:0031267]; ubiquitin binding [GO:0043130]

GO - Cellular component (CC): clathrin-coated vesicle [GO:0030136]; early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; trans-Golgi network [GO:0005802]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
LRPTLFRLA	DEG_APCC_DBOX_1	APC,CDC20,FZR1	ADP-ribosylation factor-binding protein GGA2	275:283	More..
PSSST	DEG_SPOP_SBC_1	SPOP	ADP-ribosylation factor-binding protein GGA2	399:403	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R276W	SIDM01020	Plasma Cell Myeloma	GDSC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.8634
p.R276W	ACH-000380	Myeloma	CCLE	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.8634
p.R276W	KMS-12-BM	haematopoietic and lymphoid tissue	COSMIC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.8634
p.T403M	TCGA-EE-A2MQ	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	399:403	Mutation altering degron motif	0.8534
p.T403M	DO37810	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	399:403	Mutation altering degron motif	0.8534
p.S400F	DO229462	SKCA	ICGC	PSSST	DEG_SPOP_SBC_1	399:403	Mutation altering degron motif	0.7982
p.R281W	TCGA-19-5956	GBM	TCGA	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7523
p.R281W	DO233693	GACA	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7523
p.R281W	DO13863	GBM	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7523
p.R281W	SIDM00006	Other Solid Cancers	GDSC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7523
p.R281W	ACH-001552	Skin Cancer	CCLE	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7523
p.R281W	MCC26	skin	COSMIC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7523
p.T278M	TCGA-AA-3877	COAD	TCGA	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7423
p.T278M	DO7855	COAD	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.7423
p.A283E	DO229037	LICA	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.659
p.P277H	TCGA-BR-4201	STAD	TCGA	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.6583
p.P277H	DO38707	STAD	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.6583
p.F280L	SIDM00415	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.587
p.F280L	ACH-001639	Leukemia	CCLE	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.587
p.F280L	ROS-50	haematopoietic and lymphoid tissue	COSMIC	LRPTLFRLA	DEG_APCC_DBOX_1	275:283	Mutation altering degron motif	0.587

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GGA2

UniProt ID: Q9UJY4

Entrez ID: 23062

Protein name: ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GGA2 in