DegronMD

Uniprot ID: Q9UJY4

Source protein: ADP-ribosylation factor-binding protein GGA2

Source gene: GGA2

Class: DEG_APCC_DBOX_1

Location: 275:283

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9821

ASA_SCORE: 72.8111

COIL: 0.4101

CONS_SCORE: 0.5028

DSS_SCORE: 0.3304

HELIX: 0.5568

FCONS_SCORE: 1.0825

RIG_SCORE: 0.8088

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R281W	TCGA-19-5956	GBM	TCGA	LRPTLFRLA	DEG_APCC_DBOX_1	0.7523
p.R281W	DO233693	GACA	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	0.7523
p.R281W	DO13863	GBM	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	0.7523
p.R281W	SIDM00006	Other Solid Cancers	GDSC	LRPTLFRLA	DEG_APCC_DBOX_1	0.7523
p.R281W	ACH-001552	Skin Cancer	CCLE	LRPTLFRLA	DEG_APCC_DBOX_1	0.7523
p.R281W	MCC26	skin	COSMIC	LRPTLFRLA	DEG_APCC_DBOX_1	0.7523
p.T278M	TCGA-AA-3877	COAD	TCGA	LRPTLFRLA	DEG_APCC_DBOX_1	0.7423
p.T278M	DO7855	COAD	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	0.7423
p.V268M	TCGA-B5-A3FC	UCEC	TCGA	LRPTLFRLA	DEG_APCC_DBOX_1	0.1389
p.V268M	DO41871	UCEC	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	0.1389
p.P277H	TCGA-BR-4201	STAD	TCGA	LRPTLFRLA	DEG_APCC_DBOX_1	0.6583
p.P277H	DO38707	STAD	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	0.6583
p.E270D	TCGA-CV-7243	HNSC	TCGA	LRPTLFRLA	DEG_APCC_DBOX_1	0.1944
p.E270D	DO15382	HNSC	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	0.1944
p.C272Y	DO234269	ESAD	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	0.25
p.A283E	DO229037	LICA	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	0.659
p.T287A	DO231043	LUSC	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	0.2222
p.D290N	DO229268	THCA	ICGC	LRPTLFRLA	DEG_APCC_DBOX_1	0.1389
p.R276W	SIDM01020	Plasma Cell Myeloma	GDSC	LRPTLFRLA	DEG_APCC_DBOX_1	0.8634
p.R276W	ACH-000380	Myeloma	CCLE	LRPTLFRLA	DEG_APCC_DBOX_1	0.8634
p.R276W	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	LRPTLFRLA	DEG_APCC_DBOX_1	0.8634
p.D288N	SIDM01047	Chronic Myelogenous Leukemia	GDSC	LRPTLFRLA	DEG_APCC_DBOX_1	0.1944
p.A283V	SIDM00699	Small Cell Lung Carcinoma	GDSC	LRPTLFRLA	DEG_APCC_DBOX_1	0.5825
p.A283V	ACH-001138	Lung Cancer	CCLE	LRPTLFRLA	DEG_APCC_DBOX_1	0.5825
p.A283V	NCI-H2141	lung	COSMIC	LRPTLFRLA	DEG_APCC_DBOX_1	0.5825
p.F280L	SIDM00415	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRPTLFRLA	DEG_APCC_DBOX_1	0.587
p.F280L	ACH-001639	Leukemia	CCLE	LRPTLFRLA	DEG_APCC_DBOX_1	0.587
p.F280L	ROS-50	haematopoietic_and_lymphoid_tissue	COSMIC	LRPTLFRLA	DEG_APCC_DBOX_1	0.587

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRPTLFRLA

Degron related mutations and impact score

Drug responses associated with GGA2 mutations

All proteins holding degron of LRPTLFRLA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UJY4	ADP-ribosylation factor-binding protein GGA2	DEG_APCC_DBOX_1	275:283	LRPTLFRLA	APC,CDC20,FZR1	0.9821	More...